Effect of subthalamic nucleus deep brain stimulation on dual-task cognitive and motor performance in isolated dystonia

Kelly A. Mills, Leslie C. Markun, Marta San Luciano, Rami Rizk, I. Elaine Allen, Caroline A. Racine, Philip A. Starr, Jay L. Alberts, Jill L. Ostrem

Research output: Contribution to journalArticle

Abstract

Objective: Subthalamic nucleus (STN) deep brain stimulation (DBS) can improve motor complications of Parkinson's disease (PD) but may worsen specific cognitive functions. The effect of STN DBS on cognitive function in dystonia patients is less clear. Previous reports indicate that bilateral STN stimulation in patients with PD ampli fies the decrement in cognitive-motor dual-task performance seen when moving from a single-task to dual-task paradigm. We aimed to determine if the effect of bilateral STN DBS on dual-task performance in isolated patients with dystonia, who have less cognitive impairment and no dementia, is similar to that seen in PD. Methods: Eight isolated predominantly cervical patients with dystonia treated with bilateral STN DBS, with average dystonia duration of 10.5 years and Montreal Cognitive Assessment score of 26.5, completed working memory (n-back) and motor (forced-maintenance) tests under single-task and dual-task conditions while on and off DBS. Results: A multivariate, repeated-measures analysis of variance showed no effect of stimulation status (On vs Off ) on working memory (F=0.75, p=0.39) or motor function (F=0.22, p=0.69) when performed under single-task conditions, though as working memory task difficulty increased, stimulation disrupted the accuracy of force-tracking. There was a very small worsening in working memory performance (F=9.14, p=0.019) when moving from single-task to dual-tasks when using the 'dual-task loss' analysis. Conclusions: This study suggests the effect of STN DBS on working memory and attention may be much less consequential in patients with dystonia than has been reported in PD.

Original languageEnglish (US)
Pages (from-to)404-409
Number of pages6
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume86
Issue number4
DOIs
StatePublished - Apr 1 2015

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ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Mills, K. A., Markun, L. C., San Luciano, M., Rizk, R., Allen, I. E., Racine, C. A., Starr, P. A., Alberts, J. L., & Ostrem, J. L. (2015). Effect of subthalamic nucleus deep brain stimulation on dual-task cognitive and motor performance in isolated dystonia. Journal of Neurology, Neurosurgery and Psychiatry, 86(4), 404-409. https://doi.org/10.1136/jnnp-2014-307942