Effect of structured physical activity on inflammation and immune activation profile of antiretroviral therapy-experienced children living with HIV

Bindu P. Gopalan, Mary Dias, Karthika Arumugam, Reena R. D'Souza, Mathew Perumpil, Prasanna Kulkarni, Udaykumar Ranga, Anita Shet

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To compare the markers of inflammation and immune activation in virally suppressed HIV-infected children on antiretroviral therapy, who practiced regular structured exercise comprising running and yoga to those who did not over a 2-year period. Methods: This retrospective cohort study included 72 children aged 8 to 16 years divided into 2 groups, exercisers (n = 36) and the nonexercisers (n = 36) based on their intentional physical activity. The analyses were carried out at baseline and after 2 years (Y2) for the soluble biomarkers of inflammation and immune activation (tumor necrosis factor alpha, interleukin-6, interleukin-10, interferon gamma, sCD14, and sCD163). In addition, cell-associated biomarker (CD38), lipopolysaccharides, and the gene expression of interleukin-2 and brain-derived neurotrophic factor were also measured at Y2. Results: Reduction in levels of sCD14 (effect size [ES], −0.6; 95% confidence interval [CI], −1.08 to −0.14), tumor necrosis factor alpha (ES, −0.7; 95% CI, −1.18 to −0.23), interferon gamma (ES, −0.7; 95% CI, −1.17 to −0.22), and interleukin-10 (ES, −0.6; 95% CI, −1.08 to −0.14) was observed among exercisers as compared with nonexercisers at Y2. In addition, CD38+ expressing CD4+ T cells were found to be lower among exercisers (P =.01) at Y2. However, the differences in levels of interleukin-6, sCD163, lipopolysaccharides, interleukin-2, and brain-derived neurotrophic factor were not significantly different among the 2 groups. Conclusion: The study result suggests that regular structured physical activity improves the inflammatory profile of antiretroviral therapy-treated HIV-infected children.

Original languageEnglish (US)
Pages (from-to)73-80
Number of pages8
JournalPediatric Exercise Science
Volume32
Issue number2
DOIs
StatePublished - May 2020
Externally publishedYes

Keywords

  • Exercise
  • Running and yoga
  • SCD14
  • Soluble biomarkers
  • Tumor necrosis factor alpha

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Fingerprint Dive into the research topics of 'Effect of structured physical activity on inflammation and immune activation profile of antiretroviral therapy-experienced children living with HIV'. Together they form a unique fingerprint.

Cite this