Effect of stomach motility on food hydrolysis and gastric emptying: Insight from computational models

Sharun Kuhar; Jae Ho Lee; Jung Hee Seo; Pankaj J. Pasricha; Rajat Mittal

doi:10.1063/5.0120933

Effect of stomach motility on food hydrolysis and gastric emptying: Insight from computational models

Sharun Kuhar, Jae Ho Lee, Jung Hee Seo, Pankaj J. Pasricha, Rajat Mittal

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The peristaltic motion of stomach walls combines with the secretion of digestive enzymes to initiate the process that breaks down food. In this study, the mixing, breakdown, and emptying of a liquid meal containing protein is simulated in a model of a human stomach. In this model, pepsin, the gastric enzyme responsible for protein hydrolysis, is secreted from the proximal region of the stomach walls and allowed to react with the contents of the stomach. The velocities of the retropulsive jet induced by the peristaltic motion, the emptying rate, and the extent of hydrolysis are quantified for a control case as well as for three other cases with reduced motility of the stomach, which may result from conditions such as diabetes mellitus. This study quantifies the effect of stomach motility on the rate of food breakdown and its emptying into the duodenum and we correlate these observations with the mixing in the stomach induced by the wall motion.

Original language	English (US)
Article number	111909
Journal	Physics of Fluids
Volume	34
Issue number	11
DOIs	https://doi.org/10.1063/5.0120933
State	Published - Nov 2022

ASJC Scopus subject areas

Computational Mechanics
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering
Fluid Flow and Transfer Processes

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10.1063/5.0120933

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title = "Effect of stomach motility on food hydrolysis and gastric emptying: Insight from computational models",

abstract = "The peristaltic motion of stomach walls combines with the secretion of digestive enzymes to initiate the process that breaks down food. In this study, the mixing, breakdown, and emptying of a liquid meal containing protein is simulated in a model of a human stomach. In this model, pepsin, the gastric enzyme responsible for protein hydrolysis, is secreted from the proximal region of the stomach walls and allowed to react with the contents of the stomach. The velocities of the retropulsive jet induced by the peristaltic motion, the emptying rate, and the extent of hydrolysis are quantified for a control case as well as for three other cases with reduced motility of the stomach, which may result from conditions such as diabetes mellitus. This study quantifies the effect of stomach motility on the rate of food breakdown and its emptying into the duodenum and we correlate these observations with the mixing in the stomach induced by the wall motion.",

author = "Sharun Kuhar and Lee, {Jae Ho} and Seo, {Jung Hee} and Pasricha, {Pankaj J.} and Rajat Mittal",

note = "Funding Information: We acknowledge research funding from the National Science Foundation (NSF) via Award No. CBET 2019405 and the National Institutes of Health (NIH) via Award No. 5R21GM139073-02. This work used the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by the NSF via Grant No. ACI-1548562, through Allocation No. TG-CTS100002. Publisher Copyright: {\textcopyright} 2022 Author(s).",

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AU - Mittal, Rajat

N1 - Funding Information: We acknowledge research funding from the National Science Foundation (NSF) via Award No. CBET 2019405 and the National Institutes of Health (NIH) via Award No. 5R21GM139073-02. This work used the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by the NSF via Grant No. ACI-1548562, through Allocation No. TG-CTS100002. Publisher Copyright: © 2022 Author(s).

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Effect of stomach motility on food hydrolysis and gastric emptying: Insight from computational models

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