Effect of starvation of renal metabolism in the rat

F. I. Bennett, J. E. Alexander, A. Roobol, G. A O Alleyne

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of starvation on the acid base status of the rat and on the gluconeogenic and ammoniagenic capacity of rat renal cortical slices were examined. Starvation for 48 or 72 hr did not affect acid base status, and urinary ammonia production did not change. Kidney cortical slices from starved as compared to fed rats showed increased gluconeogenic capacity when incubated with the substrates pyruvate, succinate, fumarate, malate, 2 oxoglutarate, glutamine and glutamate. Renal cortical tissue from starved rats also had increased activity of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase. Renal cortical slices from starved rats did not differ from those from fed rats in the ability to produce ammonia from glutamine or glutamate, nor was there any difference in the activity of glutaminase between these groups. These results show that renal gluconeogenic capacity is increased in starved rats in the absence of systemic acidosis, and starvation does not lead to an increase in urinary ammonia excretion or renal ammoniagenic capacity.

Original languageEnglish (US)
Pages (from-to)380-384
Number of pages5
JournalKidney International
Volume7
Issue number6
StatePublished - 1975
Externally publishedYes

ASJC Scopus subject areas

  • Nephrology

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