Effect of sleep deprivation on responses to airway obstruction in the sleeping dog

C. P. O'Donnell, E. D. King, Alan R Schwartz, Philip L Smith, J. L. Robotham

Research output: Contribution to journalArticle

Abstract

The effect of sleep deprivation on sleep architecture and respiratory responses to repetitive airway obstruction during sleep was investigated in four chronically instrumented tracheostomized dogs during 12-h nocturnal experiments. A 24-h period of prior sleep deprivation increased (P <0.05) the rate at which airway obstruction could be induced from 20 ± 3 (SE) to 37 ± 10 times/h compared with non-sleep-deprived dogs. During non-rapid-eye- movement sleep the duration of obstruction, minimum arterial hemoglobin saturation, and peak negative inspiratory effort at arousal were 20.5 ± 1.0 s, 91.7 ± 0.5%, and 28.4 ± 1.8 mmHg, respectively, in non-sleep-deprived dogs. Sleep deprivation increased (P <0.01) the duration of obstruction to 28.0 ± 0.9 s, worsened (P <0.05) the minimal arterial hemoglobin desaturation to 85.4 ± 3.1%, and increased (P <0.025) the peak negative inspiratory effort at arousal to 36.1 ± 1.6 mmHg. Sleep deprivation also caused increases (P <0.025) in total sleep time, rapid-eye-movement (REM) sleep time, and percentage of time in REM sleep in a 2-h recovery period without airway obstruction at the end of the study. We conclude that airway obstruction in the sleeping dog can reproduce the disturbances in sleep architecture and respiration that occur in obstructive sleep apnea and that prior sleep deprivation will increase apnea severity, degree of somnolence, and REM sleep rebound independent of change in upper airway collapsibility.

Original languageEnglish (US)
Pages (from-to)1811-1818
Number of pages8
JournalJournal of Applied Physiology
Volume77
Issue number4
StatePublished - 1994

Fingerprint

Sleep Deprivation
Airway Obstruction
Sleep
Dogs
REM Sleep
Arousal
Hemoglobins
Obstructive Sleep Apnea
Apnea
Eye Movements
Respiration

Keywords

  • arousal
  • endotracheal tube
  • hemoglobin saturation
  • hypoxia
  • non-rapid-eye-movement sleep
  • rapid-eye-movement sleep

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

O'Donnell, C. P., King, E. D., Schwartz, A. R., Smith, P. L., & Robotham, J. L. (1994). Effect of sleep deprivation on responses to airway obstruction in the sleeping dog. Journal of Applied Physiology, 77(4), 1811-1818.

Effect of sleep deprivation on responses to airway obstruction in the sleeping dog. / O'Donnell, C. P.; King, E. D.; Schwartz, Alan R; Smith, Philip L; Robotham, J. L.

In: Journal of Applied Physiology, Vol. 77, No. 4, 1994, p. 1811-1818.

Research output: Contribution to journalArticle

O'Donnell, CP, King, ED, Schwartz, AR, Smith, PL & Robotham, JL 1994, 'Effect of sleep deprivation on responses to airway obstruction in the sleeping dog', Journal of Applied Physiology, vol. 77, no. 4, pp. 1811-1818.
O'Donnell, C. P. ; King, E. D. ; Schwartz, Alan R ; Smith, Philip L ; Robotham, J. L. / Effect of sleep deprivation on responses to airway obstruction in the sleeping dog. In: Journal of Applied Physiology. 1994 ; Vol. 77, No. 4. pp. 1811-1818.
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