TY - JOUR
T1 - Effect of several antiviral agents on human lymphocyte functions and marrow progenitor cell proliferation
AU - Wingard, J. R.
AU - Hess, A. D.
AU - Stuart, R. K.
AU - Saral, R.
AU - Burns, W. H.
PY - 1983
Y1 - 1983
N2 - Toxicity to hematopoiesis and lymphocytic function are major considerations in the clinical applicability of antiviral agents. We have examined the toxicities of five antiviral agents showing activity against herpes viruses: vidarabine, acyclovir, (E)-5-(2-bromovinyl)-2-deoxyuridine, trifluorothymidine, and (S)-9-(2,3-dihydroxypropyl)adenine. The drugs were tested in vitro for inhibition of herpes simplex virus type 1 and human cytomegalovirus replication, effects on marrow progenitor cell growth, effects on lymphocyte responses to mitogen and alloantigen stimulation, and effects on several lymphocyte cytotoxic responses. In general, lymphocyte proliferative responses were inhibited by the various drugs at lower concentrations than were cytotoxic activities. Acyclovir and (E)-5-(2-bromovinyl)-2'-deoxyuridine were the least toxic drugs tested, with antiviral indices exceeding 10,000. Vidarabine and trifluorothymidine were more toxic, with antiviral indices generally between 10 and 100. (S)-9-(2,3-dihydroxypropyl)adenine was the most toxic, with several antiviral indices between 1 and 10.
AB - Toxicity to hematopoiesis and lymphocytic function are major considerations in the clinical applicability of antiviral agents. We have examined the toxicities of five antiviral agents showing activity against herpes viruses: vidarabine, acyclovir, (E)-5-(2-bromovinyl)-2-deoxyuridine, trifluorothymidine, and (S)-9-(2,3-dihydroxypropyl)adenine. The drugs were tested in vitro for inhibition of herpes simplex virus type 1 and human cytomegalovirus replication, effects on marrow progenitor cell growth, effects on lymphocyte responses to mitogen and alloantigen stimulation, and effects on several lymphocyte cytotoxic responses. In general, lymphocyte proliferative responses were inhibited by the various drugs at lower concentrations than were cytotoxic activities. Acyclovir and (E)-5-(2-bromovinyl)-2'-deoxyuridine were the least toxic drugs tested, with antiviral indices exceeding 10,000. Vidarabine and trifluorothymidine were more toxic, with antiviral indices generally between 10 and 100. (S)-9-(2,3-dihydroxypropyl)adenine was the most toxic, with several antiviral indices between 1 and 10.
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U2 - 10.1128/AAC.23.4.593
DO - 10.1128/AAC.23.4.593
M3 - Article
C2 - 6305264
AN - SCOPUS:0020663387
SN - 0309-1708
VL - 23
SP - 593
EP - 597
JO - Unknown Journal
JF - Unknown Journal
IS - 4
ER -