Effect of serum on cell-to-cell associations during in vitro development of preimplantation mouse embryos

Kathleen S. Morgan, Michael Edidin

Research output: Contribution to journalArticlepeer-review

Abstract

We have identified an activity which alters the morphology and developmental timing of post-compaction mouse embryos. A 15-min exposure of 4- and 8-cell mouse embryos to sera containing this activity induced monolayer formation, changing the normal positions of blastomeres at the 16- to 64-cell stages. Recovered embryos form normal blastocysts, based on morphology and in vitro production of trophectoderm and inner cell mass derivatives. These results suggest that under certain circumstances blastomeres remain developmentally labile as late as the sixth or seventh cleavage cycle.

Original languageEnglish (US)
Pages (from-to)252-255
Number of pages4
JournalDevelopmental biology
Volume116
Issue number1
DOIs
StatePublished - Jul 1986

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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