Effect of serum from patients with minimal to mild endometriosis on mouse embryo development in vitro

M. D. Damewood, J. S. Hesla, W. D. Schlaff, M. Hubbard, J. D. Gearhart, J. A. Rock

Research output: Contribution to journalArticle

Abstract

Two-cell mouse embryos were cultured at 37°C in 5% CO2, 95% air with a 7.5% serum supplement from patients with minimal to mild endometriosis, (group I, n = 31), tubal factor (group II, n = 33), male factor (group III, n = 17), fetal cord samples (group IV, n = 37), and Ham's F-10 medium (Gibco, Grand Island, NY) without a serum supplement (group V, n = 30). The progression to blastocyst stage (mean percent ± SE) at 96 hours in groups I, II, III, IV, and V was 29.9% ± 3.7%, 60.6% ± 4.9%, 56.2% ± 5.2%, 61.7% ± 5.8%, and 63.2% ± 6.9%, respectively. Serum factors appear to be associated with an inhibition of early embryogenesis, which may explain the decreased fertility rates observed in patients with minimal to mild endometriosis.

Original languageEnglish (US)
Pages (from-to)917-920
Number of pages4
JournalFertility and sterility
Volume54
Issue number5
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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    Damewood, M. D., Hesla, J. S., Schlaff, W. D., Hubbard, M., Gearhart, J. D., & Rock, J. A. (1990). Effect of serum from patients with minimal to mild endometriosis on mouse embryo development in vitro. Fertility and sterility, 54(5), 917-920. https://doi.org/10.1016/s0015-0282(16)53956-9