Effect of semen sampling frequency on seminal antiretroviral drug concentration

Y. J. Cao, T. T. Ndovi, T. L. Parsons, A. M. Guidos, B. Caffo, C. W. Hendrix

Research output: Contribution to journalArticle

Abstract

Study of male genital tract (MGT) pharmacology is relevant to the treatment of prostatitis, prostate cancer, infertility, and seminal human immunodeficiency virus transmission. However, the time course of drug concentrations in the MGT is largely unknown. To determine the feasibility of frequent semen sampling in assessing the pharmacokinetics of the MGT, we administered efavirenz, indinavir, and zidovudine to subjects to achieve steady-state levels and then collected semen samples at sequentially decreasing ejaculation intervals. The volume of seminal plasma decreased from 4.0 (1.2-5.1) ml (median with range) at 48 h after the baseline ejaculation to 0.72 (0.45-1.6) ml 1 h after a previous ejaculation, which was still adequate for drug concentration assessment. The seminal fructose concentration also decreased. However, the concentration of prostate-specific antigen and all three drugs did not decrease, even if the ejaculation intervals decreased to 1 h. Thus, semi-intensive semen sampling can be used to assess MGT pharmacokinetics.

Original languageEnglish (US)
Pages (from-to)848-856
Number of pages9
JournalClinical pharmacology and therapeutics
Volume83
Issue number6
DOIs
StatePublished - Jun 1 2008

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Effect of semen sampling frequency on seminal antiretroviral drug concentration'. Together they form a unique fingerprint.

  • Cite this