Effect of selective serotonin reuptake inhibitors on platelets in patients with coronary artery disease

Victor L. Serebruany, Christopher M. O'Connor, Paul A. Gurbel

Research output: Contribution to journalArticle


The inhibitory effects of SSRIs on platelet function observed in our study may be directly related to the association between treatment of depression and improved outcomes in patients with coronary artery disease. In recognizing antiplatelet properties of SSRIs, their combination with thienopyridines and glycoprotein IIb/IIIa inhibitors should be considered with caution. Future strategies must consider safe approaches to protect platelets from extensive activation, and for these purposes SSRIs may represent an optimal class of dual agents treating depression and simultaneously inhibiting platelets.

Original languageEnglish (US)
Pages (from-to)1398-1400
Number of pages3
JournalAmerican Journal of Cardiology
Issue number12
StatePublished - Jun 15 2001


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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