Effect of residential proximity to major roadways on cystic fibrosis exacerbations

Mandeep S. Jassal, Albert M. Yu, Rajeev Bhatia, Thomas G. Keens, Sally L.Davidson Ward

Research output: Contribution to journalArticlepeer-review


Ambient air pollution has been attributed with an increase in exacerbation frequencies among the cystic fibrosis (CF) population. This study correlates exacerbation frequency with proximity to roadways and two criteria air pollutants. Clinical data was extracted from the Cystic Fibrosis Foundation National Patient Registry and Electronic Medical Records at Children's Hospital Los Angeles (CHLA). Average annual air pollutant levels were obtained from selected US Environmental Protection Agency's monitoring stations. Geographic proximity to monitoring stations and roadways were analyzed using spatial mapping software. A total of 145 patients from the CHLA's CF center were characterized by a dichotomous exacerbation category. No significant association was determined between the frequency of exacerbations and exposure to fine particulate matter and ozone levels. Residential proximity to US-designated highways and freeways also did not achieve significance (p=0.3777) but was noted to be correlated with major arterial roadways (p=0.0420). Associations of environmental exposures may have important implications for future predictive models of CF clinical outcomes.

Original languageEnglish (US)
Pages (from-to)119-131
Number of pages13
JournalInternational Journal of Environmental Health Research
Issue number2
StatePublished - Apr 1 2013
Externally publishedYes


  • air pollution
  • cystic fibrosis
  • ozone
  • particulate matter
  • traffic

ASJC Scopus subject areas

  • Pollution
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


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