TY - GEN

T1 - Effect of regularization parameter and scan time on crossing fibers with constrained compressed sensing

AU - ElShahaby, Fatma Elzahraa A.

AU - Landman, Bennett A.

AU - Prince, Jerry L.

PY - 2011/6/9

Y1 - 2011/6/9

N2 - Diffusion tensor imaging (DTI) is an MR imaging technique that uses a set of diffusion weighted measurements in order to determine the water diffusion tensor at each voxel. In DTI, a single dominant fiber orientation is calculated at each measured voxel, even if multiple populations of fibers are present within this voxel. A new approach called Crossing Fiber Angular Resolution of Intra-voxel structure (CFARI) for processing diffusion weighted magnetic resonance data has been recently introduced. Based on compressed sensing, CFARI is able to resolve intra-voxel structure from limited number of measurements, but its performance as a function of the scan and algorithm parameters is poorly understood at present. This paper describes simulation experiments to help understand CFARI performance tradeoffs as a function of the data signal-to-noise ratio and the algorithm regularization parameter. In the compressed sensing criterion, the choice of the regularization parameter β is critical. If β is too small, then the solution is the conventional least squares solution, while if β is too large then the solution is identically zero. The correct selection of β turns out to be data dependent, which means that it is also spatially varying. In this paper, simulations using two random tensors with different diffusivities having the same fractional anisotropy but with different principle eigenvalues are carried out. Results reveal that for a fixed scan time, acquisition of repeated measurements can improve CFARI performance and that a spatially variable, data adaptive regularization parameter is beneficial in stabilizing results.

AB - Diffusion tensor imaging (DTI) is an MR imaging technique that uses a set of diffusion weighted measurements in order to determine the water diffusion tensor at each voxel. In DTI, a single dominant fiber orientation is calculated at each measured voxel, even if multiple populations of fibers are present within this voxel. A new approach called Crossing Fiber Angular Resolution of Intra-voxel structure (CFARI) for processing diffusion weighted magnetic resonance data has been recently introduced. Based on compressed sensing, CFARI is able to resolve intra-voxel structure from limited number of measurements, but its performance as a function of the scan and algorithm parameters is poorly understood at present. This paper describes simulation experiments to help understand CFARI performance tradeoffs as a function of the data signal-to-noise ratio and the algorithm regularization parameter. In the compressed sensing criterion, the choice of the regularization parameter β is critical. If β is too small, then the solution is the conventional least squares solution, while if β is too large then the solution is identically zero. The correct selection of β turns out to be data dependent, which means that it is also spatially varying. In this paper, simulations using two random tensors with different diffusivities having the same fractional anisotropy but with different principle eigenvalues are carried out. Results reveal that for a fixed scan time, acquisition of repeated measurements can improve CFARI performance and that a spatially variable, data adaptive regularization parameter is beneficial in stabilizing results.

KW - Compressed sensing

KW - Diffusion tensor Imaging

UR - http://www.scopus.com/inward/record.url?scp=79957976404&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79957976404&partnerID=8YFLogxK

U2 - 10.1117/12.878382

DO - 10.1117/12.878382

M3 - Conference contribution

C2 - 21552469

AN - SCOPUS:79957976404

SN - 9780819485045

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Medical Imaging 2011

T2 - Medical Imaging 2011: Image Processing

Y2 - 14 February 2011 through 16 February 2011

ER -