Effect of protein, unsaturated fat, and carbohydrate intakes on plasma apolipoprotein B and VLDL and LDL containing apolipoprotein C-III: Results from the OmniHeart Trial

Jeremy D. Furtado, Hannia Campos, Lawrence Appel, Edgar R Miller, Nancy Laranjo, Vincent J. Carey, Frank M. Sacks

Research output: Contribution to journalArticle

Abstract

Background: Plasma apolipoprotein B (apo B) and VLDL and LDL with apolipoprotein C-III (apo C-III) are independent risk factors for cardiovascular disease (CVD). Dietary intake affects lipoprotein concentration and composition related to those apolipoproteins. Objective: We studied differences in apo B lipoproteins with and without apo C-III after 3 healthy diets based on the Dietary Approaches to Stop Hypertension Trial diet. Design: Healthy participants (n = 162) were fed each of 3 healthy diets for 6 wk in a crossover design. Diets differed by emphasis of either carbohydrate (Carb), unsaturated fat (Unsat), or protein (Prot). Blood was collected at baseline and after diets for analysis. Results: Compared with the Carb diet, the Prot diet reduced plasma apo B and triglycerides in VLDL with apo C-III (16%, P = 0.07; 11%, P = 0.05, respectively) and apo B in LDL with apo C-III (16%, P = 0.04). Compared with the Unsat diet, the Prot diet reduced triglycerides in VLDL with apo C-III (16%, P = 0.02). Compared with baseline (subjects' usual diet was higher in saturated fat), the Prot diet reduced apo B in LDL with apo C-III (11%, P = 0.05), and all 3 diets reduced plasma total apo B (6-10%, P <0.05) and apo B in the major type of LDL, LDL without apo C-III (8-10%, P <0.01). All 3 diets reduced the ratio of apo C-III to apo E in VLDL. Conclusions: Substituting protein for carbohydrate in the context of a healthy dietary pattern reduced atherogenic apo C-III-containing LDL and its precursor, apo C-III-containing VLDL, resulting in the most favorable profile of apo B lipoproteins. In addition, compared with a typical high-saturated fat diet, healthy diets that emphasize carbohydrate, protein, or unsaturated fat reduce plasma total and LDL apo B and produce a lower more metabolically favorable ratio of apo C-III to apo E.

Original languageEnglish (US)
Pages (from-to)1623-1630
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume87
Issue number6
StatePublished - Jun 1 2008

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apolipoprotein C-III
Unsaturated Fats
Apolipoprotein C-III
apolipoprotein B
carbohydrate intake
Apolipoproteins B
fat intake
Carbohydrates
Diet
Proteins
diet
proteins
healthy diet
lipoproteins
Lipoproteins
carbohydrates
Apolipoproteins E
dietary protein
unsaturated fats
oxidized low density lipoprotein

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

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Effect of protein, unsaturated fat, and carbohydrate intakes on plasma apolipoprotein B and VLDL and LDL containing apolipoprotein C-III : Results from the OmniHeart Trial. / Furtado, Jeremy D.; Campos, Hannia; Appel, Lawrence; Miller, Edgar R; Laranjo, Nancy; Carey, Vincent J.; Sacks, Frank M.

In: American Journal of Clinical Nutrition, Vol. 87, No. 6, 01.06.2008, p. 1623-1630.

Research output: Contribution to journalArticle

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abstract = "Background: Plasma apolipoprotein B (apo B) and VLDL and LDL with apolipoprotein C-III (apo C-III) are independent risk factors for cardiovascular disease (CVD). Dietary intake affects lipoprotein concentration and composition related to those apolipoproteins. Objective: We studied differences in apo B lipoproteins with and without apo C-III after 3 healthy diets based on the Dietary Approaches to Stop Hypertension Trial diet. Design: Healthy participants (n = 162) were fed each of 3 healthy diets for 6 wk in a crossover design. Diets differed by emphasis of either carbohydrate (Carb), unsaturated fat (Unsat), or protein (Prot). Blood was collected at baseline and after diets for analysis. Results: Compared with the Carb diet, the Prot diet reduced plasma apo B and triglycerides in VLDL with apo C-III (16{\%}, P = 0.07; 11{\%}, P = 0.05, respectively) and apo B in LDL with apo C-III (16{\%}, P = 0.04). Compared with the Unsat diet, the Prot diet reduced triglycerides in VLDL with apo C-III (16{\%}, P = 0.02). Compared with baseline (subjects' usual diet was higher in saturated fat), the Prot diet reduced apo B in LDL with apo C-III (11{\%}, P = 0.05), and all 3 diets reduced plasma total apo B (6-10{\%}, P <0.05) and apo B in the major type of LDL, LDL without apo C-III (8-10{\%}, P <0.01). All 3 diets reduced the ratio of apo C-III to apo E in VLDL. Conclusions: Substituting protein for carbohydrate in the context of a healthy dietary pattern reduced atherogenic apo C-III-containing LDL and its precursor, apo C-III-containing VLDL, resulting in the most favorable profile of apo B lipoproteins. In addition, compared with a typical high-saturated fat diet, healthy diets that emphasize carbohydrate, protein, or unsaturated fat reduce plasma total and LDL apo B and produce a lower more metabolically favorable ratio of apo C-III to apo E.",
author = "Furtado, {Jeremy D.} and Hannia Campos and Lawrence Appel and Miller, {Edgar R} and Nancy Laranjo and Carey, {Vincent J.} and Sacks, {Frank M.}",
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T1 - Effect of protein, unsaturated fat, and carbohydrate intakes on plasma apolipoprotein B and VLDL and LDL containing apolipoprotein C-III

T2 - Results from the OmniHeart Trial

AU - Furtado, Jeremy D.

AU - Campos, Hannia

AU - Appel, Lawrence

AU - Miller, Edgar R

AU - Laranjo, Nancy

AU - Carey, Vincent J.

AU - Sacks, Frank M.

PY - 2008/6/1

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N2 - Background: Plasma apolipoprotein B (apo B) and VLDL and LDL with apolipoprotein C-III (apo C-III) are independent risk factors for cardiovascular disease (CVD). Dietary intake affects lipoprotein concentration and composition related to those apolipoproteins. Objective: We studied differences in apo B lipoproteins with and without apo C-III after 3 healthy diets based on the Dietary Approaches to Stop Hypertension Trial diet. Design: Healthy participants (n = 162) were fed each of 3 healthy diets for 6 wk in a crossover design. Diets differed by emphasis of either carbohydrate (Carb), unsaturated fat (Unsat), or protein (Prot). Blood was collected at baseline and after diets for analysis. Results: Compared with the Carb diet, the Prot diet reduced plasma apo B and triglycerides in VLDL with apo C-III (16%, P = 0.07; 11%, P = 0.05, respectively) and apo B in LDL with apo C-III (16%, P = 0.04). Compared with the Unsat diet, the Prot diet reduced triglycerides in VLDL with apo C-III (16%, P = 0.02). Compared with baseline (subjects' usual diet was higher in saturated fat), the Prot diet reduced apo B in LDL with apo C-III (11%, P = 0.05), and all 3 diets reduced plasma total apo B (6-10%, P <0.05) and apo B in the major type of LDL, LDL without apo C-III (8-10%, P <0.01). All 3 diets reduced the ratio of apo C-III to apo E in VLDL. Conclusions: Substituting protein for carbohydrate in the context of a healthy dietary pattern reduced atherogenic apo C-III-containing LDL and its precursor, apo C-III-containing VLDL, resulting in the most favorable profile of apo B lipoproteins. In addition, compared with a typical high-saturated fat diet, healthy diets that emphasize carbohydrate, protein, or unsaturated fat reduce plasma total and LDL apo B and produce a lower more metabolically favorable ratio of apo C-III to apo E.

AB - Background: Plasma apolipoprotein B (apo B) and VLDL and LDL with apolipoprotein C-III (apo C-III) are independent risk factors for cardiovascular disease (CVD). Dietary intake affects lipoprotein concentration and composition related to those apolipoproteins. Objective: We studied differences in apo B lipoproteins with and without apo C-III after 3 healthy diets based on the Dietary Approaches to Stop Hypertension Trial diet. Design: Healthy participants (n = 162) were fed each of 3 healthy diets for 6 wk in a crossover design. Diets differed by emphasis of either carbohydrate (Carb), unsaturated fat (Unsat), or protein (Prot). Blood was collected at baseline and after diets for analysis. Results: Compared with the Carb diet, the Prot diet reduced plasma apo B and triglycerides in VLDL with apo C-III (16%, P = 0.07; 11%, P = 0.05, respectively) and apo B in LDL with apo C-III (16%, P = 0.04). Compared with the Unsat diet, the Prot diet reduced triglycerides in VLDL with apo C-III (16%, P = 0.02). Compared with baseline (subjects' usual diet was higher in saturated fat), the Prot diet reduced apo B in LDL with apo C-III (11%, P = 0.05), and all 3 diets reduced plasma total apo B (6-10%, P <0.05) and apo B in the major type of LDL, LDL without apo C-III (8-10%, P <0.01). All 3 diets reduced the ratio of apo C-III to apo E in VLDL. Conclusions: Substituting protein for carbohydrate in the context of a healthy dietary pattern reduced atherogenic apo C-III-containing LDL and its precursor, apo C-III-containing VLDL, resulting in the most favorable profile of apo B lipoproteins. In addition, compared with a typical high-saturated fat diet, healthy diets that emphasize carbohydrate, protein, or unsaturated fat reduce plasma total and LDL apo B and produce a lower more metabolically favorable ratio of apo C-III to apo E.

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