Effect of Propiconazole on the Lipid Metabolism of Zebrafish Embryos (Danio rerio)

Miaomiao Teng, Feng Zhao, Yimeng Zhou, Sen Yan, Sinuo Tian, Jin Yan, Zhiyuan Meng, Sheng Bi, Chengju Wang

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Propiconazole is a triazole fungicide that has been widely used in agriculture and has been detected in the aquatic environment. This study aimed to investigate the effects of propiconazole exposure on lipid metabolism in the early life stages of zebrafish for 120 h postfertilization (hpf). Using the early life stages of zebrafish to address scientific questions is lower in cost, more efficient, and suitable to meeting current legislation than those in other traditional fish species. Exposure to propiconazole significantly inhibited the development of zebrafish embryos and larvae. This exposure also caused reduced locomotor activities in zebrafish. Furthermore, total cholesterol levels, lipoprotein lipase, and fatty acid synthase activities were significantly decreased. The expression levels of genes involved in lipid metabolism were significantly up-regulated in response to propiconazole exposure. GC-MS/MS analysis revealed that fatty acids were significantly decreased. Together, the findings indicate the potential environmental risks of propiconazole exposure in the aquatic ecosystem.

Original languageEnglish (US)
Pages (from-to)4623-4631
Number of pages9
JournalJournal of Agricultural and Food Chemistry
Issue number16
StatePublished - Apr 24 2019


  • fatty acids
  • lipid metabolism
  • propiconazole
  • zebrafish embryo

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)


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