Effect of prenatal and perinatal antibiotics on maternal health in Malawi, Tanzania, and Zambia

Said Aboud, Gernard Msamanga, Jennifer S. Read, Lei Wang, Chelu Mfalila, Usha Sharma, Francis Martinson, Taha E. Taha, Robert L. Goldenberg, Wafaie W. Fawzi

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: We assessed the effect of prenatal and peripartum antibiotics on maternal morbidity and mortality among HIV-infected and uninfected women. Methods: A multicenter trial was conducted at clinical sites in 4 Sub-Saharan African cities: Blantyre and Lilongwe, Malawi; Dar es Salaam, Tanzania; and Lusaka, Zambia. A total of 1558 HIV-infected and 271 uninfected pregnant women who were eligible to receive both the prenatal and peripartum antibiotic/placebo regimens were enrolled. Pregnant women were interviewed at 20-24 weeks of gestation and a physical examination was performed. Women were randomized to receive either antibiotics or placebo. At the 26-30 week visit, participants were given antibiotics or placebo to be taken every 4 hours beginning at the onset of labor and continuing after delivery 3 times a day until a 1-week course was completed. Logistic regression and Cox proportional hazards models were used. Results: There were no significant differences between the antibiotic and placebo groups for medical conditions, obstetric complications, physical examination findings, puerperal sepsis, and death in either the HIV-infected or the uninfected cohort. Conclusion: Administration of study antibiotics during pregnancy had no effect on maternal morbidity and mortality among HIV-infected and uninfected pregnant women.

Original languageEnglish (US)
Pages (from-to)202-207
Number of pages6
JournalInternational Journal of Gynecology and Obstetrics
Volume107
Issue number3
DOIs
StatePublished - Dec 2009

Keywords

  • Antibiotics
  • HIV
  • Maternal morbidity
  • Maternal mortality
  • Pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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