Effect of preinjury statin use on mortality and septic shock in elderly burn patients

Mary D. Fogerty, David Efron, Alessandro Morandi, Jeffrey S. Guy, Naji N. Abumrad, Adrian Barbul

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Premorbid statin use has been associated with decreased mortality in septic and trauma patients. This has been ascribed to the pleiotropic, anti-inflammatory effects of HMG-CoA reductase inhibitors. This association has not been investigated in burn victims. Methods: A retrospective review of 223 consecutive patients, aged 55 years and older admitted to Vanderbilt University Regional Burn Center from January 2006 to December 2008, was performed. Multivariate regression analysis determined odds ratios of death and sepsis by statin use, adjusting for cardiovascular comorbidities. Results: Of 223 patients, 70 (31.4%) were taking statins before admission. Mean age and mean total body surface area burn were not significantly different by statin use. The odds ratio of inhospital death was 0.17 (95% confidence interval 0.05-0.57; p = 0.004) if on statins. The odds ratio of mortality when stratified by cardiovascular comorbidities did not change. Sepsis developed in 30 patients (13.5%), with an odds ratio in statin users of 0.50 (95% confidence interval 0.20-1.30; p = 0.155). Conclusion: Preinjury statin use was associated with an 83% reduction in the odds of death after thermal injury. The odds of sepsis decreased by 50%, although not statistically significant. Further study is warranted to investigate the potential benefits of statin therapy in the management of burn victims.

Original languageEnglish (US)
Pages (from-to)99-103
Number of pages5
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume69
Issue number1
DOIs
StatePublished - Jul 1 2010

Keywords

  • Burn
  • Elderly
  • Sepsis
  • Statin

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

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