Effect of preexposure to triazoles on susceptibility and virulence of Rhizopus oryzae

Anne Pauline Bellanger, Nathaniel D. Albert, Russell E. Lewis, Thomas J. Walsh, Dimitrios P. Kontoyiannis

Research output: Contribution to journalArticlepeer-review

Abstract

Triazole prophylaxis has become the norm in patients with hematological malignancies. Breakthrough infections caused by Mucorales during triazole prophylaxis remain a challenging problem. We found that preexposure of Rhizopus oryzae to antifungal triazoles (fluconazole, voriconazole, posaconazole, and itraconazole) did not modify the in vitro susceptibility of Rhizopus oryzae to posaconazole. In contrast, preexposure of Rhizopus to triazoles was associated with the enhanced in vitro susceptibility of R. oryzae to amphotericin B. Preexposure to posaconazole did not alter the virulence of R. oryzae in the fly model of mucormycosis.

Original languageEnglish (US)
Pages (from-to)7830-7832
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume59
Issue number12
DOIs
StatePublished - Dec 1 2015

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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