TY - JOUR
T1 - Effect of preexposure to triazoles on susceptibility and virulence of Rhizopus oryzae
AU - Bellanger, Anne Pauline
AU - Albert, Nathaniel D.
AU - Lewis, Russell E.
AU - Walsh, Thomas J.
AU - Kontoyiannis, Dimitrios P.
N1 - Funding Information:
D. P. Kontoyiannis received research support and honoraria from Merck, Inc., Astellas, Inc., Pfizer, Mylan, Inc., and T2 Biosystems. D. P. Kontoyiannis acknowledges the Frances King Blank Endowment for Cancer Research. T. J. Walsh is a scholar in mucormycosis of the Henry Schueler Foundation and a Scholar of the Sharp Family Foundation in pediatric infectious diseases. T. J. Walsh received research grants from Astellas, Cubist, Theravance, the Medicines Company, Novartis, Merck, Contra-Fect, Pfizer, Drais, iCo, Methyl Gene, Sigma Tau, and Trius. All other authors declare no conflicts of interest.
Publisher Copyright:
Copyright © 2015, American Society for Microbiology. All Rights Reserved.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Triazole prophylaxis has become the norm in patients with hematological malignancies. Breakthrough infections caused by Mucorales during triazole prophylaxis remain a challenging problem. We found that preexposure of Rhizopus oryzae to antifungal triazoles (fluconazole, voriconazole, posaconazole, and itraconazole) did not modify the in vitro susceptibility of Rhizopus oryzae to posaconazole. In contrast, preexposure of Rhizopus to triazoles was associated with the enhanced in vitro susceptibility of R. oryzae to amphotericin B. Preexposure to posaconazole did not alter the virulence of R. oryzae in the fly model of mucormycosis.
AB - Triazole prophylaxis has become the norm in patients with hematological malignancies. Breakthrough infections caused by Mucorales during triazole prophylaxis remain a challenging problem. We found that preexposure of Rhizopus oryzae to antifungal triazoles (fluconazole, voriconazole, posaconazole, and itraconazole) did not modify the in vitro susceptibility of Rhizopus oryzae to posaconazole. In contrast, preexposure of Rhizopus to triazoles was associated with the enhanced in vitro susceptibility of R. oryzae to amphotericin B. Preexposure to posaconazole did not alter the virulence of R. oryzae in the fly model of mucormycosis.
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U2 - 10.1128/AAC.01583-15
DO - 10.1128/AAC.01583-15
M3 - Article
C2 - 26392499
AN - SCOPUS:84954524497
SN - 0066-4804
VL - 59
SP - 7830
EP - 7832
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 12
ER -