Effect of potassium supplementation on blood pressure in African Americans on a low-potassium diet

A randomized, double-blind, placebo-controlled trial

Frederick L. Brancati, Lawrence Appel, Alexander J. Seidler, Paul K. Whelton

Research output: Contribution to journalArticle

Abstract

Objective: To determine the effect of potassium supplementation on blood pressure in African Americans consuming a low-potassium diet. Design: Randomized, double-blind, placebo-controlled trial with two parallel arms. Setting: Community-based research site. Participants: Eighty-seven healthy African Americans aged 27 to 65 years with a systolic blood pressure between 100 and 159 mm Hg and a diastolic blood pressure between 70 and 94 mm Hg. Intervention: During the 21-day intervention period, all participants were provided with a low-potassium diet (32 to 35 mmol/d). In addition to this diet, they were randomly assigned to receive either potassium supplements (80 mmol/d) or placebo. Main Outcome Measure: Change in blood pressure in the potassium vs the placebo group, based on a total of nine blood pressure readings at three visits. Blood pressures were taken before and during the intervention by means of random-zero sphygmomanometry. Results: At baseline, the placebo and potassium groups were similar for mean blood pressure (127/78 vs 125/77 mm Hg), 24-hour urinary potassium excretion (50 vs 44 mmol), and all other variables measured (all P>.05). During the intervention, the net difference in 24-hour urinary potassium excretion between groups was 70 mmol. Compared with the placebo group, the potassium supplementation group experienced a net decline in systolic blood pressure of 6.9 mm Hg (95% confidence interval, -9.3 to -4.4 mm Hg; P

Original languageEnglish (US)
Pages (from-to)61-67
Number of pages7
JournalArchives of Internal Medicine
Volume156
Issue number1
DOIs
StatePublished - Jan 8 1996

Fingerprint

African Americans
Potassium
Placebos
Diet
Blood Pressure
Reading
Outcome Assessment (Health Care)
Confidence Intervals

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Effect of potassium supplementation on blood pressure in African Americans on a low-potassium diet : A randomized, double-blind, placebo-controlled trial. / Brancati, Frederick L.; Appel, Lawrence; Seidler, Alexander J.; Whelton, Paul K.

In: Archives of Internal Medicine, Vol. 156, No. 1, 08.01.1996, p. 61-67.

Research output: Contribution to journalArticle

@article{57024dac37c64dbdaea491645eccbe3e,
title = "Effect of potassium supplementation on blood pressure in African Americans on a low-potassium diet: A randomized, double-blind, placebo-controlled trial",
abstract = "Objective: To determine the effect of potassium supplementation on blood pressure in African Americans consuming a low-potassium diet. Design: Randomized, double-blind, placebo-controlled trial with two parallel arms. Setting: Community-based research site. Participants: Eighty-seven healthy African Americans aged 27 to 65 years with a systolic blood pressure between 100 and 159 mm Hg and a diastolic blood pressure between 70 and 94 mm Hg. Intervention: During the 21-day intervention period, all participants were provided with a low-potassium diet (32 to 35 mmol/d). In addition to this diet, they were randomly assigned to receive either potassium supplements (80 mmol/d) or placebo. Main Outcome Measure: Change in blood pressure in the potassium vs the placebo group, based on a total of nine blood pressure readings at three visits. Blood pressures were taken before and during the intervention by means of random-zero sphygmomanometry. Results: At baseline, the placebo and potassium groups were similar for mean blood pressure (127/78 vs 125/77 mm Hg), 24-hour urinary potassium excretion (50 vs 44 mmol), and all other variables measured (all P>.05). During the intervention, the net difference in 24-hour urinary potassium excretion between groups was 70 mmol. Compared with the placebo group, the potassium supplementation group experienced a net decline in systolic blood pressure of 6.9 mm Hg (95{\%} confidence interval, -9.3 to -4.4 mm Hg; P",
author = "Brancati, {Frederick L.} and Lawrence Appel and Seidler, {Alexander J.} and Whelton, {Paul K.}",
year = "1996",
month = "1",
day = "8",
doi = "10.1001/archinte.156.1.61",
language = "English (US)",
volume = "156",
pages = "61--67",
journal = "JAMA Internal Medicine",
issn = "2168-6106",
publisher = "American Medical Association",
number = "1",

}

TY - JOUR

T1 - Effect of potassium supplementation on blood pressure in African Americans on a low-potassium diet

T2 - A randomized, double-blind, placebo-controlled trial

AU - Brancati, Frederick L.

AU - Appel, Lawrence

AU - Seidler, Alexander J.

AU - Whelton, Paul K.

PY - 1996/1/8

Y1 - 1996/1/8

N2 - Objective: To determine the effect of potassium supplementation on blood pressure in African Americans consuming a low-potassium diet. Design: Randomized, double-blind, placebo-controlled trial with two parallel arms. Setting: Community-based research site. Participants: Eighty-seven healthy African Americans aged 27 to 65 years with a systolic blood pressure between 100 and 159 mm Hg and a diastolic blood pressure between 70 and 94 mm Hg. Intervention: During the 21-day intervention period, all participants were provided with a low-potassium diet (32 to 35 mmol/d). In addition to this diet, they were randomly assigned to receive either potassium supplements (80 mmol/d) or placebo. Main Outcome Measure: Change in blood pressure in the potassium vs the placebo group, based on a total of nine blood pressure readings at three visits. Blood pressures were taken before and during the intervention by means of random-zero sphygmomanometry. Results: At baseline, the placebo and potassium groups were similar for mean blood pressure (127/78 vs 125/77 mm Hg), 24-hour urinary potassium excretion (50 vs 44 mmol), and all other variables measured (all P>.05). During the intervention, the net difference in 24-hour urinary potassium excretion between groups was 70 mmol. Compared with the placebo group, the potassium supplementation group experienced a net decline in systolic blood pressure of 6.9 mm Hg (95% confidence interval, -9.3 to -4.4 mm Hg; P

AB - Objective: To determine the effect of potassium supplementation on blood pressure in African Americans consuming a low-potassium diet. Design: Randomized, double-blind, placebo-controlled trial with two parallel arms. Setting: Community-based research site. Participants: Eighty-seven healthy African Americans aged 27 to 65 years with a systolic blood pressure between 100 and 159 mm Hg and a diastolic blood pressure between 70 and 94 mm Hg. Intervention: During the 21-day intervention period, all participants were provided with a low-potassium diet (32 to 35 mmol/d). In addition to this diet, they were randomly assigned to receive either potassium supplements (80 mmol/d) or placebo. Main Outcome Measure: Change in blood pressure in the potassium vs the placebo group, based on a total of nine blood pressure readings at three visits. Blood pressures were taken before and during the intervention by means of random-zero sphygmomanometry. Results: At baseline, the placebo and potassium groups were similar for mean blood pressure (127/78 vs 125/77 mm Hg), 24-hour urinary potassium excretion (50 vs 44 mmol), and all other variables measured (all P>.05). During the intervention, the net difference in 24-hour urinary potassium excretion between groups was 70 mmol. Compared with the placebo group, the potassium supplementation group experienced a net decline in systolic blood pressure of 6.9 mm Hg (95% confidence interval, -9.3 to -4.4 mm Hg; P

UR - http://www.scopus.com/inward/record.url?scp=0030051009&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030051009&partnerID=8YFLogxK

U2 - 10.1001/archinte.156.1.61

DO - 10.1001/archinte.156.1.61

M3 - Article

VL - 156

SP - 61

EP - 67

JO - JAMA Internal Medicine

JF - JAMA Internal Medicine

SN - 2168-6106

IS - 1

ER -