Effect of post-operative analgesia on patient morbidity

Christopher L. Wu, Matthew D. Caldwell

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


The pathophysiology that commonly follows surgery results in detrimental physiological effects and may be associated with post-operative mortality and morbidity. The use of post-operative epidural analgesia, but not systemic opioids, may attenuate some of these adverse physiological effects and result in a decrease in patient-related morbidity post-operatively. Randomized trials suggest that the perioperative use of epidural analgesia may facilitate return of gastrointestinal function, attenuate hypercoagulable events and diminish post-operative pulmonary complications. A multimodal approach incorporating the use of epidural analgesia to control perioperative pathophysiology will facilitate the patient's recovery.

Original languageEnglish (US)
Pages (from-to)549-563
Number of pages15
JournalBest Practice and Research: Clinical Anaesthesiology
Issue number4
StatePublished - Dec 2002


  • Epidural analgesia
  • Post-operative pain

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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