Effect of polymethylmethacrylate particles on human articular cartilage cells in vitro

C. Frondoza, K. Tanner, M. Widra, L. Jones, D. Hungerford

Research output: Contribution to conferencePaperpeer-review

Abstract

In this study, we attempted to determine whether PMMA particles stimulate the proliferative capacity and metabolic activity of normal human articular cartilage cells. In addition, the hip or knee joint wear products in these arthroplasties may affect the survival of the non-replaced portion of the joint. Articular cartilage cells incubated with PMMA displayed two patterns of DNA synthesis profiles (TABLE 1) Cells from one group of patients (Pattern A), showed decreased proliferative capacity following PMMA exposure. In the second group of patients (Pattern B), exposure of cells to PMMA induced insignificant to increased proliferative capacity.

Original languageEnglish (US)
Number of pages1
StatePublished - Jan 1 1991
Event17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium - Scottsdale, AZ, USA
Duration: May 1 1991May 5 1991

Other

Other17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium
CityScottsdale, AZ, USA
Period5/1/915/5/91

ASJC Scopus subject areas

  • Materials Science(all)

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