Effect of polyethylene wear debris on synoviocytes

C. Frondoza, A. Sohrabi, S. Bendall, K. Kohilas, D. S. Hungerford, R. H. Jinnah

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The study was conducted to test the hypothesis that ultra high molecular weight polyethylene (UHMWPE) debris isolated from periprosthetic tissue can be evaluated for its effect on tissue cells in a spinner culture model. Synoviocytes were used as target cells because of their accessibility to wear debris and their ability to produce cytokines and proteases known to mediate inflammation and osteolysis. The experiment successfully evaluated the effect of UHMWPE on tissue cells by using a microcarrier suspension culture. It was found that UHMWPE induces cytokine production and cell death, indicating that the polymer debris is capable of mediating inflammation and tissue destruction.

Original languageEnglish (US)
Title of host publicationTransactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium
Editors Anon
PublisherSoc for Biomaterials
Pages899
Number of pages1
Volume1
StatePublished - 1996
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

Fingerprint

Polyethylene
Debris
Ultrahigh molecular weight polyethylenes
Polyethylenes
Wear of materials
Tissue
Cytokines
Cell death
Suspensions
Polymers
Peptide Hydrolases
ultra-high molecular weight polyethylene
Experiments

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Frondoza, C., Sohrabi, A., Bendall, S., Kohilas, K., Hungerford, D. S., & Jinnah, R. H. (1996). Effect of polyethylene wear debris on synoviocytes. In Anon (Ed.), Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium (Vol. 1, pp. 899). Soc for Biomaterials.

Effect of polyethylene wear debris on synoviocytes. / Frondoza, C.; Sohrabi, A.; Bendall, S.; Kohilas, K.; Hungerford, D. S.; Jinnah, R. H.

Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. ed. / Anon. Vol. 1 Soc for Biomaterials, 1996. p. 899.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Frondoza, C, Sohrabi, A, Bendall, S, Kohilas, K, Hungerford, DS & Jinnah, RH 1996, Effect of polyethylene wear debris on synoviocytes. in Anon (ed.), Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. vol. 1, Soc for Biomaterials, pp. 899, Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, 5/29/96.
Frondoza C, Sohrabi A, Bendall S, Kohilas K, Hungerford DS, Jinnah RH. Effect of polyethylene wear debris on synoviocytes. In Anon, editor, Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. Vol. 1. Soc for Biomaterials. 1996. p. 899
Frondoza, C. ; Sohrabi, A. ; Bendall, S. ; Kohilas, K. ; Hungerford, D. S. ; Jinnah, R. H. / Effect of polyethylene wear debris on synoviocytes. Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. editor / Anon. Vol. 1 Soc for Biomaterials, 1996. pp. 899
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