Effect of polyethylene wear debris on synoviocytes

C. Frondoza, A. Sohrabi, S. Bendall, K. Kohilas, D. S. Hungerford, R. H. Jinnah

Research output: Contribution to conferencePaperpeer-review

1 Scopus citations


The study was conducted to test the hypothesis that ultra high molecular weight polyethylene (UHMWPE) debris isolated from periprosthetic tissue can be evaluated for its effect on tissue cells in a spinner culture model. Synoviocytes were used as target cells because of their accessibility to wear debris and their ability to produce cytokines and proteases known to mediate inflammation and osteolysis. The experiment successfully evaluated the effect of UHMWPE on tissue cells by using a microcarrier suspension culture. It was found that UHMWPE induces cytokine production and cell death, indicating that the polymer debris is capable of mediating inflammation and tissue destruction.

Original languageEnglish (US)
Number of pages1
StatePublished - Dec 1 1996
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996


OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can

ASJC Scopus subject areas

  • Materials Science(all)


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