Effect of Photic Injury on the Retinal Tissues

Mark O.M. Tso, Barbara J. Woodford

Research output: Contribution to journalArticlepeer-review

Abstract

In order to study the tissue damages in photic injury of the retina, the macula and posterior pole of the rhesus monkey were exposed to the light of an indirect ophthalmoscope. During the acute phase of the injury, disruption of the blood-retinal barrier appeared to be an early and sensitive indicator of retinal pigment epithelial damage and cyclic-GMP-phosphodiesterase of the photoreceptor lamella was inactivated. These lesions were followed for 2 to 5 years. Focal chronic decompensation of the blood-retinal barrier and subretinal pigment epithelial neovascularization were noted in the chronic degenerative phase of this photic maculopathy. A possible protective role of ascorbic acid in mild photic injury was proposed.

Original languageEnglish (US)
Pages (from-to)952-963
Number of pages12
JournalOphthalmology
Volume90
Issue number8
DOIs
StatePublished - 1983

Keywords

  • ascorbic acid
  • cyclic-GMP-phosphodiesterase
  • horseradish peroxidase
  • monkey
  • photoreceptor cells
  • phototoxicity
  • pigment epithelium
  • retina

ASJC Scopus subject areas

  • Ophthalmology

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