Effect of phosphorus restriction on renal response to oral and intravenous protein loads in rats

Edward Kraus, Linda Cheng, Ilze Sikorski, David A. Spector

Research output: Contribution to journalArticle

Abstract

Dietary phosphorus restriction ameliorates renal injury in rats. This may be due to changes in renal hemodynamics, including those factors associated with protein-induced hyperfiltration. To test this, we measured inulin clearance (CIn), p-aminohippuric acid clearance (CPAH), mean arterial blood pressure, and renal vascular resistance (RVR) 1h before and 100 min after either oral gavage of 2 g bovine serum albumin or intravenous infusion of 5% glycine in female Sprague-Dawley rats previously fed for 3-8 wk a 0.5% or a 0.1% phosphorus diet. Baseline CIn, CPAH, blood pressure, and RVR were similar. After albumin gavage, CIn rose 20% (P <0.01) for the 0.5% phosphorus group but did not change for rats fed the 0.1% phosphorus diet. Other measured parameters, including plasma glucagon and renin activity, were not influenced by dietary phosphorus content. In contrast, during intravenous infusion of glycine, hyperfiltration was induced in phosphorus-restricted rats. Thus dietary phosphorus restriction ablates oral protein but not intravenous amino acid-induced hyperfiltration, suggesting a gut-mediated mechanism for the former. These data highlight the potential importance of dietary phosphorus as a mediator of renal hemodynamics.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume264
Issue number4 33-4
StatePublished - 1993

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Dietary Phosphorus
Phosphorus
Kidney
p-Aminohippuric Acid
Proteins
Intravenous Infusions
Vascular Resistance
Glycine
Arterial Pressure
Hemodynamics
Diet
Inulin
Bovine Serum Albumin
Glucagon
Renin
Sprague Dawley Rats
Albumins
Blood Pressure
Amino Acids
Wounds and Injuries

Keywords

  • Hyperfiltration
  • Hypophosphatemia
  • Renal functional reserve

ASJC Scopus subject areas

  • Physiology

Cite this

Effect of phosphorus restriction on renal response to oral and intravenous protein loads in rats. / Kraus, Edward; Cheng, Linda; Sikorski, Ilze; Spector, David A.

In: American Journal of Physiology - Renal Fluid and Electrolyte Physiology, Vol. 264, No. 4 33-4, 1993.

Research output: Contribution to journalArticle

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