Effect of Pharmacologic Prophylaxis on Venous Thromboembolism After Radical Prostatectomy: The PREVENTER Randomized Clinical Trial

Hiten D. Patel; Farzana A. Faisal; Bruce J. Trock; Gregory A. Joice; Zeyad R. Schwen; Phillip M. Pierorazio; Michael H. Johnson; Trinity J. Bivalacqua; Misop Han; Michael A. Gorin; H. Ballentine Carter; Alan W. Partin; Christian P. Pavlovich; Mohamad E. Allaf

doi:10.1016/j.eururo.2020.05.001

Effect of Pharmacologic Prophylaxis on Venous Thromboembolism After Radical Prostatectomy: The PREVENTER Randomized Clinical Trial

Hiten D. Patel, Farzana A. Faisal, Bruce J. Trock, Gregory A. Joice, Zeyad R. Schwen, Phillip M. Pierorazio, Michael H. Johnson, Trinity J. Bivalacqua, Misop Han, Michael A. Gorin, H. Ballentine Carter, Alan W. Partin, Christian P. Pavlovich, Mohamad E. Allaf

School of Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

In the Prevention of Venous Thromboembolism Following Radical Prostatectomy (PREVENTER) randomized trial, pharmacologic prophylaxis did not reduce the rate of symptomatic (relative risk [RR] 0.40 [95% confidence interval {CI} 0.08–2.03], p = 0.267) or overall (RR 0.97 [95% CI 0.25–3.81], p = 0.967) venous thromboembolism significantly. There was no increase in adverse events including symptomatic lymphoceles or bleeding.

Original language	English (US)
Pages (from-to)	360-368
Number of pages	9
Journal	European Urology
Volume	78
Issue number	3
DOIs	https://doi.org/10.1016/j.eururo.2020.05.001
State	Published - Sep 2020

Keywords

Clinical trial
Evidence-based medicine
Quality improvement
Radical prostatectomy
Surgery
Venous thromboembolism

ASJC Scopus subject areas

Urology

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10.1016/j.eururo.2020.05.001

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Patel, H. D., Faisal, F. A., Trock, B. J., Joice, G. A., Schwen, Z. R., Pierorazio, P. M., Johnson, M. H., Bivalacqua, T. J., Han, M., Gorin, M. A., Carter, H. B., Partin, A. W., Pavlovich, C. P., & Allaf, M. E. (2020). Effect of Pharmacologic Prophylaxis on Venous Thromboembolism After Radical Prostatectomy: The PREVENTER Randomized Clinical Trial. European Urology, 78(3), 360-368. https://doi.org/10.1016/j.eururo.2020.05.001

Patel, HD, Faisal, FA, Trock, BJ, Joice, GA, Schwen, ZR, Pierorazio, PM, Johnson, MH, Bivalacqua, TJ, Han, M, Gorin, MA, Carter, HB, Partin, AW, Pavlovich, CP & Allaf, ME 2020, 'Effect of Pharmacologic Prophylaxis on Venous Thromboembolism After Radical Prostatectomy: The PREVENTER Randomized Clinical Trial', European Urology, vol. 78, no. 3, pp. 360-368. https://doi.org/10.1016/j.eururo.2020.05.001

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title = "Effect of Pharmacologic Prophylaxis on Venous Thromboembolism After Radical Prostatectomy: The PREVENTER Randomized Clinical Trial",

abstract = "In the Prevention of Venous Thromboembolism Following Radical Prostatectomy (PREVENTER) randomized trial, pharmacologic prophylaxis did not reduce the rate of symptomatic (relative risk [RR] 0.40 [95% confidence interval {CI} 0.08–2.03], p = 0.267) or overall (RR 0.97 [95% CI 0.25–3.81], p = 0.967) venous thromboembolism significantly. There was no increase in adverse events including symptomatic lymphoceles or bleeding.",

keywords = "Clinical trial, Evidence-based medicine, Quality improvement, Radical prostatectomy, Surgery, Venous thromboembolism",

author = "Patel, {Hiten D.} and Faisal, {Farzana A.} and Trock, {Bruce J.} and Joice, {Gregory A.} and Schwen, {Zeyad R.} and Pierorazio, {Phillip M.} and Johnson, {Michael H.} and Bivalacqua, {Trinity J.} and Misop Han and Gorin, {Michael A.} and Carter, {H. Ballentine} and Partin, {Alan W.} and Pavlovich, {Christian P.} and Allaf, {Mohamad E.}",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = sep,

doi = "10.1016/j.eururo.2020.05.001",

language = "English (US)",

volume = "78",

pages = "360--368",

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AU - Faisal, Farzana A.

AU - Trock, Bruce J.

AU - Joice, Gregory A.

AU - Schwen, Zeyad R.

AU - Pierorazio, Phillip M.

AU - Johnson, Michael H.

AU - Bivalacqua, Trinity J.

AU - Han, Misop

AU - Gorin, Michael A.

AU - Carter, H. Ballentine

AU - Partin, Alan W.

AU - Pavlovich, Christian P.

AU - Allaf, Mohamad E.

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N2 - In the Prevention of Venous Thromboembolism Following Radical Prostatectomy (PREVENTER) randomized trial, pharmacologic prophylaxis did not reduce the rate of symptomatic (relative risk [RR] 0.40 [95% confidence interval {CI} 0.08–2.03], p = 0.267) or overall (RR 0.97 [95% CI 0.25–3.81], p = 0.967) venous thromboembolism significantly. There was no increase in adverse events including symptomatic lymphoceles or bleeding.

AB - In the Prevention of Venous Thromboembolism Following Radical Prostatectomy (PREVENTER) randomized trial, pharmacologic prophylaxis did not reduce the rate of symptomatic (relative risk [RR] 0.40 [95% confidence interval {CI} 0.08–2.03], p = 0.267) or overall (RR 0.97 [95% CI 0.25–3.81], p = 0.967) venous thromboembolism significantly. There was no increase in adverse events including symptomatic lymphoceles or bleeding.

KW - Clinical trial

KW - Evidence-based medicine

KW - Quality improvement

KW - Radical prostatectomy

KW - Surgery

KW - Venous thromboembolism

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JF - European Urology

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ER -

Effect of Pharmacologic Prophylaxis on Venous Thromboembolism After Radical Prostatectomy: The PREVENTER Randomized Clinical Trial

Abstract

Keywords

ASJC Scopus subject areas

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