Effect of pH on the in vitro potency of clarithromycin against Mycobacterium avium complex

C. Truffot-Pernot, B. Ji, J. Grosset

Research output: Contribution to journalArticlepeer-review

Abstract

Employing 7H11 agar medium at pH 6.6, the MICs of clarithromycin for 50% (MIC50) and 90% (MIC90) of 19 strains of Mycobacterium avium complex were 8 and 16 μg/ml, respectively. However, the MICs were 2 to 3 log2 dilutions lower in the 7H11 medium adjusted to pH 7.4, and the MICs on 10% OADC (oleic acid-albumin-dextrose-catalase)-enriched Mueller-Hinton agar at pH 7.3 were also 2 log2 dilutions lower than those measured on 7H11 agar at pH 6.6. Therefore, clarithromycin is more active at a physiologic than at an acidic pH.

Original languageEnglish (US)
Pages (from-to)1677-1678
Number of pages2
JournalAntimicrobial agents and chemotherapy
Volume35
Issue number8
DOIs
StatePublished - 1991

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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