Effect of penbutolol on lidocaine kinetics

H. R. Ochs, D. Skanderra, D. R. Abernethy, D. J. Greenblatt

Research output: Contribution to journalArticlepeer-review


The effect of penbutolol (Betapressin®), a stereospecific β-adrenergic antagonist, on the pharmacokinetics of a single dose of intravenous lidocaine was evaluated in seven healthy volunteers. Subjects received a single 100-mg lidocaine intravenous dose of lidocaine hydrochloride, one in the control state and a second time during coadministration of penbutolol, 60 mg daily. Lidocaine volume of distribution was significantly increased during penbutolol treatment (4.9 vs 3.4 l/kg, p<0.005), resulting in a significant prolongation of elimination half-life (2.5 vs 2.0 h, p<0.025). The mechanism of the distributional shift is not established, but may result from a change in the pattern of peripheral blood flow and therefore the profile of tissue uptake of lidocaine. Total metabolic clearance of lidocaine, however, was not significantly altered by penbutolol (23.0 vs 19.4 ml/min/kg). The present study of healthy volunteers suggests that penbutolol increases lidocaine volume of distribution. If the finding also applied to patients, a higher loading dose of lidocaine might be necessary.

Original languageEnglish (US)
Pages (from-to)1680-1681
Number of pages2
JournalArzneimittel-Forschung/Drug Research
Issue number12
StatePublished - 1983

ASJC Scopus subject areas

  • Drug Discovery


Dive into the research topics of 'Effect of penbutolol on lidocaine kinetics'. Together they form a unique fingerprint.

Cite this