Effect of penbutolol on lidocaine kinetics

H. R. Ochs, D. Skanderra, D. R. Abernethy, D. J. Greenblatt

Research output: Contribution to journalArticle

Abstract

The effect of penbutolol (Betapressin®), a stereospecific β-adrenergic antagonist, on the pharmacokinetics of a single dose of intravenous lidocaine was evaluated in seven healthy volunteers. Subjects received a single 100-mg lidocaine intravenous dose of lidocaine hydrochloride, one in the control state and a second time during coadministration of penbutolol, 60 mg daily. Lidocaine volume of distribution was significantly increased during penbutolol treatment (4.9 vs 3.4 l/kg, p

Original languageEnglish (US)
Pages (from-to)1680-1681
Number of pages2
JournalArzneimittel-Forschung/Drug Research
Volume33
Issue number12
StatePublished - 1983
Externally publishedYes

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Penbutolol
Lidocaine
Kinetics
Adrenergic Antagonists
Pharmacokinetics
Healthy Volunteers

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Ochs, H. R., Skanderra, D., Abernethy, D. R., & Greenblatt, D. J. (1983). Effect of penbutolol on lidocaine kinetics. Arzneimittel-Forschung/Drug Research, 33(12), 1680-1681.

Effect of penbutolol on lidocaine kinetics. / Ochs, H. R.; Skanderra, D.; Abernethy, D. R.; Greenblatt, D. J.

In: Arzneimittel-Forschung/Drug Research, Vol. 33, No. 12, 1983, p. 1680-1681.

Research output: Contribution to journalArticle

Ochs, HR, Skanderra, D, Abernethy, DR & Greenblatt, DJ 1983, 'Effect of penbutolol on lidocaine kinetics', Arzneimittel-Forschung/Drug Research, vol. 33, no. 12, pp. 1680-1681.
Ochs HR, Skanderra D, Abernethy DR, Greenblatt DJ. Effect of penbutolol on lidocaine kinetics. Arzneimittel-Forschung/Drug Research. 1983;33(12):1680-1681.
Ochs, H. R. ; Skanderra, D. ; Abernethy, D. R. ; Greenblatt, D. J. / Effect of penbutolol on lidocaine kinetics. In: Arzneimittel-Forschung/Drug Research. 1983 ; Vol. 33, No. 12. pp. 1680-1681.
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