Effect of peer health workers on AIDS care in Rakai, Uganda: A cluster-randomized trial

Larry Chang, Joseph Kagaayi, Gertrude Nakigozi, Victor Ssempijja, Arnold H. Packer, David Serwadda, Thomas C Quinn, Ronald H Gray, Robert C Bollinger, Steven James Reynolds

Research output: Contribution to journalArticle

Abstract

Background Human resource limitations are a challenge to the delivery of antiretroviral therapy (ART) in low-resource settings. We conducted a cluster randomized trial to assess the effect of community-based peer health workers (PHW) on AIDS care of adults in Rakai, Uganda. Methodology/Principal Findings 15 AIDS clinics were randomized 2:1 to receive the PHW intervention (n = 10) or control (n = 5). PHW tasks included clinic and home-based provision of counseling, clinical, adherence to ART, and social support. Primary outcomes were adherence and cumulative risk of virologic failure (>400 copies/mL). Secondary outcomes were virologic failure at each 24 week time point up to 192 weeks of ART. Analysis was by intention to treat. From May 2006 to July 2008, 1336 patients were followed. 444 (33%) of these patients were already on ART at the start of the study. No significant differences were found in lack of adherence (

Original languageEnglish (US)
Article numbere10923
JournalPLoS One
Volume5
Issue number6
DOIs
StatePublished - 2010

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Uganda
peers
health care workers
Acquired Immunodeficiency Syndrome
Health
therapeutics
cumulative risk
Intention to Treat Analysis
counseling
Therapeutics
Social Support
Personnel
human resources
Counseling
methodology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Effect of peer health workers on AIDS care in Rakai, Uganda : A cluster-randomized trial. / Chang, Larry; Kagaayi, Joseph; Nakigozi, Gertrude; Ssempijja, Victor; Packer, Arnold H.; Serwadda, David; Quinn, Thomas C; Gray, Ronald H; Bollinger, Robert C; Reynolds, Steven James.

In: PLoS One, Vol. 5, No. 6, e10923, 2010.

Research output: Contribution to journalArticle

Chang, Larry ; Kagaayi, Joseph ; Nakigozi, Gertrude ; Ssempijja, Victor ; Packer, Arnold H. ; Serwadda, David ; Quinn, Thomas C ; Gray, Ronald H ; Bollinger, Robert C ; Reynolds, Steven James. / Effect of peer health workers on AIDS care in Rakai, Uganda : A cluster-randomized trial. In: PLoS One. 2010 ; Vol. 5, No. 6.
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