Effect of particulate PMMA in a canine model of loosened orthopaedic implants

L. C. Jones, C. Frondoza, D. S. Hungerford

Research output: Contribution to conferencePaper

Abstract

A study was conducted to extensively characterize a canine model of aseptic loosening of an orthopedic implant using undecalcified histology and immunohistochemistry. It was shown that the movement of the implant prevented bone formation in the defect and leads to the development of a bursa-like membrane. In combination with particulate PMMA, there was an increase in the number of cells and cytokines associated with a chronic inflammatory response within the membrane. This is in turn associated with an increase in the bone resorption at the interface. In contrast, there was no evidence of an inflammatory response to the stationary PMMA-coated plugs, with or without particulates.

Original languageEnglish (US)
Number of pages1
StatePublished - Dec 1 1996
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

ASJC Scopus subject areas

  • Materials Science(all)

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    Jones, L. C., Frondoza, C., & Hungerford, D. S. (1996). Effect of particulate PMMA in a canine model of loosened orthopaedic implants. Paper presented at Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, .