Effect of particulate PMMA in a canine model of loosened orthopaedic implants

Lynne C Jones, C. Frondoza, D. S. Hungerford

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A study was conducted to extensively characterize a canine model of aseptic loosening of an orthopedic implant using undecalcified histology and immunohistochemistry. It was shown that the movement of the implant prevented bone formation in the defect and leads to the development of a bursa-like membrane. In combination with particulate PMMA, there was an increase in the number of cells and cytokines associated with a chronic inflammatory response within the membrane. This is in turn associated with an increase in the bone resorption at the interface. In contrast, there was no evidence of an inflammatory response to the stationary PMMA-coated plugs, with or without particulates.

Original languageEnglish (US)
Title of host publicationTransactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium
Editors Anon
PublisherSoc for Biomaterials
Pages902
Number of pages1
Volume1
StatePublished - 1996
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

Fingerprint

Orthopedics
Polymethyl Methacrylate
Bone
Membranes
Histology
Cytokines
Defects
Immunohistochemistry

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Jones, L. C., Frondoza, C., & Hungerford, D. S. (1996). Effect of particulate PMMA in a canine model of loosened orthopaedic implants. In Anon (Ed.), Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium (Vol. 1, pp. 902). Soc for Biomaterials.

Effect of particulate PMMA in a canine model of loosened orthopaedic implants. / Jones, Lynne C; Frondoza, C.; Hungerford, D. S.

Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. ed. / Anon. Vol. 1 Soc for Biomaterials, 1996. p. 902.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Jones, LC, Frondoza, C & Hungerford, DS 1996, Effect of particulate PMMA in a canine model of loosened orthopaedic implants. in Anon (ed.), Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. vol. 1, Soc for Biomaterials, pp. 902, Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, 5/29/96.
Jones LC, Frondoza C, Hungerford DS. Effect of particulate PMMA in a canine model of loosened orthopaedic implants. In Anon, editor, Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. Vol. 1. Soc for Biomaterials. 1996. p. 902
Jones, Lynne C ; Frondoza, C. ; Hungerford, D. S. / Effect of particulate PMMA in a canine model of loosened orthopaedic implants. Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. editor / Anon. Vol. 1 Soc for Biomaterials, 1996. pp. 902
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