Effect of partial gastrectomy on serum anti-Helicobacter pylori immunoglobulins in peptic ulcer patients

Cornelis B H W Lamers, Paul N M A Rieu, Roeland A. Veenendaal, Wim Van Duijn, G. Johan A Offerhaus, Harry J M Joosten, A. Salvador Peña

Research output: Contribution to journalArticle

Abstract

Since biliary enterogastric reflux is suggested to eradicate gastric infection with Helicobacter pylori (HP), we have investigated in a prospective randomized study the effect of partial gastrectomy with either Billroth II or Roux-en-Y anastomosis on infection with HP as assessed by the titers of IgG and IgA antibodies against HP in serum. These antibodies were measured by ELISA in serum of 22 patients before and at 10 days and 6, 15, and 24 months after either Billroth II (N=11) or Roux-en-Y (N=11) gastrectomy for peptic ulcer. All patients had HP demonstrated in their preoperative endoscopic gastric biopsies. The preoperative serum IgA antibodies against HP (anti-HP IgA) were increased in 20 of the 22 patients (range 0.21-1.69) while the IgG antibodies (anti-HP IgG) were increased in all 22 patients (range 0.38-1.31). Four of the Billroth II patients had clearance of HP from gastric biopsies accompanied by rapid and pronounced decrease of anti-HP IgA. In contrast, the patients with Roux-en-Y gastrectomy and the Billroth II patients with persistent HP infection had no change in anti-HP IgA after surgery. Anti-HP IgG showed variable results in the four patients without gastric HP infection and was not affected by gastrectomy in the patients with persistent HP infection. We concluded that serum anti-HP IgA, but not anti-HP IgG, is helpful in identifying those patients in whom HP is no longer demonstrable after Billroth II gastrectomy. Gastrectomy with Roux-en-Y anastomosis had no effect on gastric HP infection.

Original languageEnglish (US)
Pages (from-to)1697-1701
Number of pages5
JournalDigestive Diseases and Sciences
Volume36
Issue number12
DOIs
StatePublished - Dec 1991
Externally publishedYes

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Gastrectomy
Peptic Ulcer
Helicobacter pylori
Immunoglobulins
Serum
Gastroenterostomy
Immunoglobulin A
Helicobacter Infections
Stomach
Immunoglobulin G
Roux-en-Y Anastomosis
Antibodies
Biopsy
Infection

Keywords

  • Helicobacter pylori
  • partial gastrectomy
  • peptic ulcer

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Lamers, C. B. H. W., Rieu, P. N. M. A., Veenendaal, R. A., Van Duijn, W., Offerhaus, G. J. A., Joosten, H. J. M., & Peña, A. S. (1991). Effect of partial gastrectomy on serum anti-Helicobacter pylori immunoglobulins in peptic ulcer patients. Digestive Diseases and Sciences, 36(12), 1697-1701. https://doi.org/10.1007/BF01296612

Effect of partial gastrectomy on serum anti-Helicobacter pylori immunoglobulins in peptic ulcer patients. / Lamers, Cornelis B H W; Rieu, Paul N M A; Veenendaal, Roeland A.; Van Duijn, Wim; Offerhaus, G. Johan A; Joosten, Harry J M; Peña, A. Salvador.

In: Digestive Diseases and Sciences, Vol. 36, No. 12, 12.1991, p. 1697-1701.

Research output: Contribution to journalArticle

Lamers, CBHW, Rieu, PNMA, Veenendaal, RA, Van Duijn, W, Offerhaus, GJA, Joosten, HJM & Peña, AS 1991, 'Effect of partial gastrectomy on serum anti-Helicobacter pylori immunoglobulins in peptic ulcer patients', Digestive Diseases and Sciences, vol. 36, no. 12, pp. 1697-1701. https://doi.org/10.1007/BF01296612
Lamers CBHW, Rieu PNMA, Veenendaal RA, Van Duijn W, Offerhaus GJA, Joosten HJM et al. Effect of partial gastrectomy on serum anti-Helicobacter pylori immunoglobulins in peptic ulcer patients. Digestive Diseases and Sciences. 1991 Dec;36(12):1697-1701. https://doi.org/10.1007/BF01296612
Lamers, Cornelis B H W ; Rieu, Paul N M A ; Veenendaal, Roeland A. ; Van Duijn, Wim ; Offerhaus, G. Johan A ; Joosten, Harry J M ; Peña, A. Salvador. / Effect of partial gastrectomy on serum anti-Helicobacter pylori immunoglobulins in peptic ulcer patients. In: Digestive Diseases and Sciences. 1991 ; Vol. 36, No. 12. pp. 1697-1701.
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