Effect of Nutritional Route on Colonic Anastomotic Healing in the Rat

Teruo Kiyama, David Thomas Efron, Udaya Tantry, Adrian Barbul

Research output: Contribution to journalArticle

Abstract

Although early enterai feeding has been shown to benefit cutaneous healing when compared to patenteral feeding, the effect of the route of nutritional support in gastrointestinal anastomotic healing has not been defined. The aim of the present study was to determine whether the route of nutritional support influences colonic anastomotic healing. Twenty male Sprague-Dawley rats weighing 270 to 290 grams underwent identical surgical manipulation consisting of central venous catheterization, gastrostomy insertion, and distal colonic anastomosis (single-layer, inverted). Identical nutrient infusates composed of 4.25% amino acids, 25% dextrose, and vitamins were administered, with half the animals receiving the infusions via the gastrostomy and the other half via the venous catheter. Animals were killed 5 days after surgery. There were no differences in nutritional parameters between the parenterally and enterally fed groups. Colonic anastomotic bursting pressure was significantly higher in the enterally fed group (180 ± 6 vs. 150 ± 11 mm Hg; P

Original languageEnglish (US)
Pages (from-to)441-446
Number of pages6
JournalJournal of Gastrointestinal Surgery
Volume3
Issue number4
StatePublished - Jul 1999

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Gastrostomy
Nutritional Support
Central Venous Catheterization
Ambulatory Surgical Procedures
Vitamins
Sprague Dawley Rats
Catheters
Amino Acids
Pressure
Glucose
Food
Skin

Keywords

  • Colon anastomosis
  • Enteral-enteral nutrition

ASJC Scopus subject areas

  • Surgery

Cite this

Effect of Nutritional Route on Colonic Anastomotic Healing in the Rat. / Kiyama, Teruo; Efron, David Thomas; Tantry, Udaya; Barbul, Adrian.

In: Journal of Gastrointestinal Surgery, Vol. 3, No. 4, 07.1999, p. 441-446.

Research output: Contribution to journalArticle

Kiyama, Teruo ; Efron, David Thomas ; Tantry, Udaya ; Barbul, Adrian. / Effect of Nutritional Route on Colonic Anastomotic Healing in the Rat. In: Journal of Gastrointestinal Surgery. 1999 ; Vol. 3, No. 4. pp. 441-446.
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