Effect of nordihydroguaiaretic acid on cerebral blood flow and metabolism during hypoxia in Newborn piglets

Jan M. Goplerud, Jane E. McGowan, Peter J. Marro, Maria Delivoria-Papadopoulos

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Abstract

Nordihydroguaiaretic acid (NDGA), a lipoxygenase inhibitor, was investigated for its effect on cerebral blood flow (CBF) and cortical oxygen consumption during hypoxia in 9 anesthetized, ventilated newborn piglets. CBF was measured by radioactive microspheres while brain cortical metabolism was evaluated by continuous 31P-NMR spectroscopy. Five piglets were treated with NDGA (3 mg/kg i.v. in 50% ethanol as vehicle) prior to hypoxia and had CBF measured before NDGA (control), 15 min after NDGA (baseline) and then after 15 and 45 min of hypoxia following NDGA. Another 4 piglets were treated with vehicle (2 ml/kg 50% ethanol) under the same protocol. In the NDGA-treated piglets, cerebral cortical O2 consumption for a given PCr/Pi was significantly increased (p <0.05) compared to non-NDGA. Since NDGA inhibits production of vasoconstricting leukotrienes during hypoxia, cortical capillary beds otherwise constricted may be perfused following NDGA, thus increasing the O2-consuming tissue area.

Original languageEnglish (US)
Pages (from-to)425-431
Number of pages7
JournalNeonatology
Volume67
Issue number6
DOIs
Publication statusPublished - 1995
Externally publishedYes

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Keywords

  • Brain
  • Cerebral blood flow
  • Cerebral metabolism
  • Hypoxia
  • Leukotrienes
  • Lipoxygenase
  • Microspheres

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

Cite this

Goplerud, J. M., McGowan, J. E., Marro, P. J., & Delivoria-Papadopoulos, M. (1995). Effect of nordihydroguaiaretic acid on cerebral blood flow and metabolism during hypoxia in Newborn piglets. Neonatology, 67(6), 425-431. https://doi.org/10.1159/000244195