Effect of nitroprusside on hydraulic vascular loads on the right and left ventricle of patients with heart failure

Research output: Contribution to journalArticle

Abstract

We studied the effect of nitroprusside on the hydraulic vascular load of the right and left ventricle in seven patients with severe left ventricular failure. At doses of 0.25-0.75 μg/kg/min, stroke volume increased progressively from 40.1 to 48.6 ml and left ventricular end-diastolic pressure decreased from 24.5 to 11.2 mm Hg. Accompanying the improvement in left ventricular performance were dose-related in mean ventricular pressures, pulmonic and systemic resistances and the lower-frequency components of input impedance moduli. Characteristic impedance and both total oscillatory external power were decreased in the pulmonic, but not the aortic, vasculature. In this class of patients, right ventricular unloading is a striking and direct effect of nitroprusside and may account, in part, for improved left ventricular performance through ventricular interdependence.

Original languageEnglish (US)
Pages (from-to)1330-1339
Number of pages10
JournalCirculation
Volume67
Issue number6 I
StatePublished - 1983
Externally publishedYes

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Nitroprusside
Electric Impedance
Heart Ventricles
Blood Vessels
Heart Failure
Lung
Patient Rights
Ventricular Pressure
Stroke Volume
Blood Pressure

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Effect of nitroprusside on hydraulic vascular loads on the right and left ventricle of patients with heart failure",
abstract = "We studied the effect of nitroprusside on the hydraulic vascular load of the right and left ventricle in seven patients with severe left ventricular failure. At doses of 0.25-0.75 μg/kg/min, stroke volume increased progressively from 40.1 to 48.6 ml and left ventricular end-diastolic pressure decreased from 24.5 to 11.2 mm Hg. Accompanying the improvement in left ventricular performance were dose-related in mean ventricular pressures, pulmonic and systemic resistances and the lower-frequency components of input impedance moduli. Characteristic impedance and both total oscillatory external power were decreased in the pulmonic, but not the aortic, vasculature. In this class of patients, right ventricular unloading is a striking and direct effect of nitroprusside and may account, in part, for improved left ventricular performance through ventricular interdependence.",
author = "Yin, {C. P.} and Guzman, {P. A.} and Brin, {K. P.} and Maughan, {William L} and Brinker, {Jeffrey A} and Traill, {Thomas A} and Weiss, {James L} and Myron Weisfeldt",
year = "1983",
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volume = "67",
pages = "1330--1339",
journal = "Circulation",
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number = "6 I",

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TY - JOUR

T1 - Effect of nitroprusside on hydraulic vascular loads on the right and left ventricle of patients with heart failure

AU - Yin, C. P.

AU - Guzman, P. A.

AU - Brin, K. P.

AU - Maughan, William L

AU - Brinker, Jeffrey A

AU - Traill, Thomas A

AU - Weiss, James L

AU - Weisfeldt, Myron

PY - 1983

Y1 - 1983

N2 - We studied the effect of nitroprusside on the hydraulic vascular load of the right and left ventricle in seven patients with severe left ventricular failure. At doses of 0.25-0.75 μg/kg/min, stroke volume increased progressively from 40.1 to 48.6 ml and left ventricular end-diastolic pressure decreased from 24.5 to 11.2 mm Hg. Accompanying the improvement in left ventricular performance were dose-related in mean ventricular pressures, pulmonic and systemic resistances and the lower-frequency components of input impedance moduli. Characteristic impedance and both total oscillatory external power were decreased in the pulmonic, but not the aortic, vasculature. In this class of patients, right ventricular unloading is a striking and direct effect of nitroprusside and may account, in part, for improved left ventricular performance through ventricular interdependence.

AB - We studied the effect of nitroprusside on the hydraulic vascular load of the right and left ventricle in seven patients with severe left ventricular failure. At doses of 0.25-0.75 μg/kg/min, stroke volume increased progressively from 40.1 to 48.6 ml and left ventricular end-diastolic pressure decreased from 24.5 to 11.2 mm Hg. Accompanying the improvement in left ventricular performance were dose-related in mean ventricular pressures, pulmonic and systemic resistances and the lower-frequency components of input impedance moduli. Characteristic impedance and both total oscillatory external power were decreased in the pulmonic, but not the aortic, vasculature. In this class of patients, right ventricular unloading is a striking and direct effect of nitroprusside and may account, in part, for improved left ventricular performance through ventricular interdependence.

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VL - 67

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EP - 1339

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