Effect of nitroglycerin and dipyridamole on regional left ventricular blood flow during coronary artery occlusion

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Abstract

Coronary vasodilators have been variously reported to increase, decrease, or have no effect upon blood flow to ischemic myocardium. Consequently, the effects of two different types of dilators, nitroglycerin (TNG) and dipyridamole, were studied with radioactive microspheres in open chested dogs after coronary artery ligation. Given as a bolus i.v. injection, 0.4 mg TNG resulted in an increase in blood flow to nonischemic areas of myocardium and a preservation of flow to ischemic regions, despite a fall in blood pressure. 5 min later blood pressure and nonischemic flow were back to base line, and a small selective increase in flow to ischemic myocardium was found (0.15-0.18 ml/min per g, P

Original languageEnglish (US)
Pages (from-to)1287-1296
Number of pages10
JournalJournal of Clinical Investigation
Volume58
Issue number6
Publication statusPublished - 1976
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

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