Effect of nedocromil sodium on neurogenic mechanisms in vitro

Allen C. Myers, Margerita M. Riccio, Bradley J Undem

Research output: Contribution to journalArticle

Abstract

We have developed a guinea pig model that allows monitoring of single afferent nerve fiber activity after stimulation of tracheal nerve endings with various stimuli. Action potentials from nodose or jugular neurons are recorded extracellularly. Previous experiments have shown that the excitability of the nerve endings to, for example, mechanical stimuli can be increased by antigen challenge of presensitized ghinea pigs. Nedocromil sodium 10-4 mol/L significantly reduced by more than 50% the generation of action potentials in C fibers in response to stimulation by capsaicin. The precise mechanism is not known, although the membrane depolarization induced by capsaicin was reduced in the presence of nedocromil sodium. This agent did not have a generalized inhibitory effect on afferent excitability because it had no effect on sensitivity to electrical or mechanical stimuli. Nedocromil sodium did not affect the generation of action potentials in Aδ and C fibers in the presence of hypertonic saline solution.

Original languageEnglish (US)
JournalThe Journal of Allergy and Clinical Immunology
Volume98
Issue number5 PART 2
StatePublished - 1996

Fingerprint

Nedocromil
Action Potentials
Unmyelinated Nerve Fibers
Nerve Endings
Capsaicin
Hypertonic Saline Solutions
Myelinated Nerve Fibers
Nerve Fibers
Guinea Pigs
Neck
Swine
Neurons
Antigens
Membranes
In Vitro Techniques

Keywords

  • Afferent
  • airways
  • axon-reflex
  • efferent
  • nodose ganglia
  • parasympathetic ganglia
  • sensory nerve
  • vagus nerve

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Effect of nedocromil sodium on neurogenic mechanisms in vitro. / Myers, Allen C.; Riccio, Margerita M.; Undem, Bradley J.

In: The Journal of Allergy and Clinical Immunology, Vol. 98, No. 5 PART 2, 1996.

Research output: Contribution to journalArticle

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