TY - JOUR
T1 - Effect of naloxone on plasma insulin, insulin-like growth factor I, and its binding protein 1 in patients with polycystic ovarian disease
AU - Laatikainen, T.
AU - Anttila, L.
AU - Suikkari, A. M.
AU - Ruutiainen, K.
AU - Erkkola, R.
AU - Seppala, M.
N1 - Funding Information:
Received February 27, 1990; revised and accepted May 14, 1990. * Supported by grants from the Academy of Finland, Helsinki, Finland; the Sigrid Juselius Foundation, Helsinki, Finland; and the Finnish Social Insurance Institution, Helsinki, Finland. t Departments of Obstetrics and Gynecology, University of Helsinki. :j: Present address: Departments of Obstetrics and Gynecology, University of Oulu. § Departments of Obstetrics and Gynecology, University of Turku.
PY - 1990
Y1 - 1990
N2 - Insulin and insulin-like growth factors (IGFs) stimulate ovarian steroidogenesis, and hyperinsulinemia is often accompanied by hyperandrogenemia in women with polycystic ovarian disease (PCOD). Because opioid peptides are involved in the regulation of insulin secretion, we studied the effect of naloxone-induced opiate receptor blockade on the circulating levels of insulin, IGF-I, and IGF binding protein 1 (IGFBP-1) in 13 nonobese and 7 obese PCOD patients and in 6 healthy subjects. In obese PCOD patients, the mean basal insulin concentration was significantly higher and the IGFBP-1 concentration lower than in nonobese PCOD patients. Plasma IGF-I levels were elevated both in obese and nonobese PCOD patients. After an intravenous bolus of 10 mg naloxone, no significant changes were found in the circulating insulin or IGF-I levels, whereas IGFBP-1 levels decreased in nonobese PCOD patients and remained low in obese PCOD patients. No significant decrease was found in healthy subjects. These results suggest that, in addition to insulin, endogenous opioids are involved in the regulation of serum IGFBP-1 level.
AB - Insulin and insulin-like growth factors (IGFs) stimulate ovarian steroidogenesis, and hyperinsulinemia is often accompanied by hyperandrogenemia in women with polycystic ovarian disease (PCOD). Because opioid peptides are involved in the regulation of insulin secretion, we studied the effect of naloxone-induced opiate receptor blockade on the circulating levels of insulin, IGF-I, and IGF binding protein 1 (IGFBP-1) in 13 nonobese and 7 obese PCOD patients and in 6 healthy subjects. In obese PCOD patients, the mean basal insulin concentration was significantly higher and the IGFBP-1 concentration lower than in nonobese PCOD patients. Plasma IGF-I levels were elevated both in obese and nonobese PCOD patients. After an intravenous bolus of 10 mg naloxone, no significant changes were found in the circulating insulin or IGF-I levels, whereas IGFBP-1 levels decreased in nonobese PCOD patients and remained low in obese PCOD patients. No significant decrease was found in healthy subjects. These results suggest that, in addition to insulin, endogenous opioids are involved in the regulation of serum IGFBP-1 level.
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U2 - 10.1016/s0015-0282(16)53757-1
DO - 10.1016/s0015-0282(16)53757-1
M3 - Article
C2 - 1697813
AN - SCOPUS:0025126852
SN - 0015-0282
VL - 54
SP - 434
EP - 437
JO - Fertility and sterility
JF - Fertility and sterility
IS - 3
ER -