Effect of modifying quantum dot surface charge on airway epithelial cell uptake in vitro

Eric Chau, Justin F. Galloway, Antoinette Nelson, Patrick N. Breysse, Denis Wirtz, Peter C. Searson, Venkataramana K. Sidhaye

Research output: Contribution to journalArticle

Abstract

The respiratory system is one of the portals of entry into the body, and hence inhalation of engineered nanomaterials is an important route of exposure. The broad range of physicochemical properties that influence biological responses necessitate the systematic study to contribute to understanding occupational exposure. Here, we report on the influence of nanoparticle charge and dose on human airway epithelial cells, and show that this platform can be used to evaluate consequences of exposure to engineered nanomaterials.

Original languageEnglish (US)
Pages (from-to)1143-1151
Number of pages9
JournalNanotoxicology
Volume7
Issue number6
DOIs
StatePublished - Sep 1 2013

Keywords

  • Airway epithelial cells
  • Epithelial barrier function
  • Nanoparticles
  • Quantum dots

ASJC Scopus subject areas

  • Biomedical Engineering
  • Toxicology

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