Effect of modifying quantum dot surface charge on airway epithelial cell uptake in vitro

Eric Chau; Justin F. Galloway; Antoinette Nelson; Patrick N. Breysse; Denis Wirtz; Peter C. Searson; Venkataramana K. Sidhaye

doi:10.3109/17435390.2012.711862

Effect of modifying quantum dot surface charge on airway epithelial cell uptake in vitro

Eric Chau, Justin F. Galloway, Antoinette Nelson, Patrick N. Breysse, Denis Wirtz, Peter C. Searson, Venkataramana K. Sidhaye

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The respiratory system is one of the portals of entry into the body, and hence inhalation of engineered nanomaterials is an important route of exposure. The broad range of physicochemical properties that influence biological responses necessitate the systematic study to contribute to understanding occupational exposure. Here, we report on the influence of nanoparticle charge and dose on human airway epithelial cells, and show that this platform can be used to evaluate consequences of exposure to engineered nanomaterials.

Original language	English (US)
Pages (from-to)	1143-1151
Number of pages	9
Journal	Nanotoxicology
Volume	7
Issue number	6
DOIs	https://doi.org/10.3109/17435390.2012.711862
State	Published - 2012

Keywords

Airway epithelial cells
Epithelial barrier function
Nanoparticles
Quantum dots

ASJC Scopus subject areas

Biomedical Engineering
Toxicology

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10.3109/17435390.2012.711862

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title = "Effect of modifying quantum dot surface charge on airway epithelial cell uptake in vitro",

abstract = "The respiratory system is one of the portals of entry into the body, and hence inhalation of engineered nanomaterials is an important route of exposure. The broad range of physicochemical properties that influence biological responses necessitate the systematic study to contribute to understanding occupational exposure. Here, we report on the influence of nanoparticle charge and dose on human airway epithelial cells, and show that this platform can be used to evaluate consequences of exposure to engineered nanomaterials.",

keywords = "Airway epithelial cells, Epithelial barrier function, Nanoparticles, Quantum dots",

author = "Eric Chau and Galloway, {Justin F.} and Antoinette Nelson and Breysse, {Patrick N.} and Denis Wirtz and Searson, {Peter C.} and Sidhaye, {Venkataramana K.}",

note = "Funding Information: This work was supported by the FAMRI Young Investigator Award and K08HL085763. JG and PS acknowledge support from NIH U54CA151838. Support for PNB was provided by NSF 0837946.",

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T1 - Effect of modifying quantum dot surface charge on airway epithelial cell uptake in vitro

AU - Chau, Eric

AU - Galloway, Justin F.

AU - Nelson, Antoinette

AU - Breysse, Patrick N.

AU - Wirtz, Denis

AU - Searson, Peter C.

AU - Sidhaye, Venkataramana K.

N1 - Funding Information: This work was supported by the FAMRI Young Investigator Award and K08HL085763. JG and PS acknowledge support from NIH U54CA151838. Support for PNB was provided by NSF 0837946.

PY - 2012

Y1 - 2012

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AB - The respiratory system is one of the portals of entry into the body, and hence inhalation of engineered nanomaterials is an important route of exposure. The broad range of physicochemical properties that influence biological responses necessitate the systematic study to contribute to understanding occupational exposure. Here, we report on the influence of nanoparticle charge and dose on human airway epithelial cells, and show that this platform can be used to evaluate consequences of exposure to engineered nanomaterials.

KW - Airway epithelial cells

KW - Epithelial barrier function

KW - Nanoparticles

KW - Quantum dots

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Effect of modifying quantum dot surface charge on airway epithelial cell uptake in vitro

Abstract

Keywords

ASJC Scopus subject areas

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