Acute forebrain ischemia reperfusion injury of rat was produced by permanent occlusion of the vertebral arteries and followed by temporary clamping of bilateral common carotid arteries. Methylflavonolamine (MFA) 10 and 20mg · kg-1 were injected intravenously 5 min before ischemia, 5 min before reperfusion, and 30 min after reperfusion, respectively. Biochemical assays of brain tissue showed MFA dose-dependently decreased calcium elevation and malondialdehyde content, suppressed the reduction of lactate dehydrogenase activity after 40 min ischemia followed by 1 h reperfusion. MFA also reduced brain edema, improved electroencephalogram and ameliorated pathologic changes. It is concluded that MFA possesses protective effect on forebrain ischemia reperfusion injury of rat. The underlying MFA mechanism of protection might be ascribed partly or mainly to its calcium antagonism.
|Original language||English (US)|
|Number of pages||4|
|Journal||Chinese Journal of Pharmacology and Toxicology|
|State||Published - 1996|
- cerebral ischemia
- reperfusion injury
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