Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate measures in the dorsolateral prefrontal cortex

Stefano Marenco, Sonya U. Steele, Michael F. Egan, Terry E. Goldberg, Richard E. Straub, Anjail Z. Sharrief, Daniel Weinberger

Research output: Contribution to journalArticle

Abstract

Objective: This study was carried out to confirm prior evidence of an effect of a single nucleotide polymorphism (SNP) in the metabotropic glutamate receptor 3 (GRM3) gene (a putative risk factor for schizophrenia) on measures of N-acetylaspartate in healthy comparison subjects. Method: Fifty-four carefully screened healthy volunteers genotyped at SNP rs6465084 underwent magnetic resonance spectroscopic imaging (MRSI) at 3 T and selected neuropsychological testing. Results: The A/A genotype group exhibited a significant reduction of N-acetylaspartate/creatine levels in the right dorsolateral prefrontal cortex compared to the G carriers. A tendency in the same direction was seen in the left dorsolateral prefrontal cortex and in the white matter adjacent to the prefrontal cortex. Conclusions: These findings provide further evidence that GRM3 affects prefrontal function and that variation in GRM3, monitored by SNP rs6465084, affects GRM3 function.

Original languageEnglish (US)
Pages (from-to)740-742
Number of pages3
JournalAmerican Journal of Psychiatry
Volume163
Issue number4
DOIs
StatePublished - Apr 2006
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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