Effect of maternal zinc supplementation on the cardiometabolic profile of Peruvian children: Results from a randomized clinical trial

M. L. Mispireta, L. E. Caulfield, N. Zavaleta, M. Merialdi, D. L. Putnick, M. H. Bornstein, J. A. DiPietro

Research output: Contribution to journalArticlepeer-review

Abstract

Zinc is an essential micronutrient for the development of the fetal renal, cardiovascular and metabolic systems; however, there is limited evidence of its effects on the postnatal cardiometabolic function. In this study, we evaluated the effect of maternal zinc supplementation during pregnancy on the cardiometabolic profile of the offspring in childhood. A total of 242 pregnant women were randomly assigned to receive a daily supplement containing iron+folic acid with or without zinc. A follow-up study was conducted when children of participating mothers were 4.5 years of age to evaluate their cardiometabolic profile, including anthropometric measures of body size and composition, blood pressure, lipid profile and insulin resistance. No difference in measures of child cardiometabolic risk depending on whether mothers received supplemental zinc during pregnancy. Our results do not support the hypothesis that maternal zinc supplementation reduces the risk of offspring cardiometabolic disease.

Original languageEnglish (US)
Pages (from-to)56-64
Number of pages9
JournalJournal of Developmental Origins of Health and Disease
Volume8
Issue number1
DOIs
StatePublished - Feb 1 2017

Keywords

  • cardiovascular
  • metabolic
  • zinc

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Fingerprint Dive into the research topics of 'Effect of maternal zinc supplementation on the cardiometabolic profile of Peruvian children: Results from a randomized clinical trial'. Together they form a unique fingerprint.

Cite this