Effect of magnesium, zinc and fluoride ions on osteoblast proliferation and phenotype expression

R. Z. LeGeros, M. Grzanna, A. Polotsky, S. Lin, C. G. Frondoza

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The effects on the proliferation and phenotype expression of osteoblasts by single or combined ions of magnesium (Mn), zinc (Zn) and flouride (Fl) which are released from the calcium phosphate (CaP) matrix were analyzed. The MG63 model of osteoblasts (bone-forming cells) was used to determine the effects of test biomaterials consisting of calcium phosphate matrixes (BCPs) on proliferation. It was found that all the materials tested significantly increased the proliferative capacity of osteoblast-like MG63 cells. It was also found that the biomaterials consisting of calcium phosphate matrixes are viable biomaterials for osteoporosis therapy and bone repair.

Original languageEnglish (US)
Title of host publicationTransactions - 7th World Biomaterials Congress
Pages1443
Number of pages1
StatePublished - 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period5/17/045/21/04

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Osteoblasts
Calcium phosphate
Biomaterials
Magnesium
Zinc
Bone
Ions
Repair

ASJC Scopus subject areas

  • Engineering(all)

Cite this

LeGeros, R. Z., Grzanna, M., Polotsky, A., Lin, S., & Frondoza, C. G. (2004). Effect of magnesium, zinc and fluoride ions on osteoblast proliferation and phenotype expression. In Transactions - 7th World Biomaterials Congress (pp. 1443)

Effect of magnesium, zinc and fluoride ions on osteoblast proliferation and phenotype expression. / LeGeros, R. Z.; Grzanna, M.; Polotsky, A.; Lin, S.; Frondoza, C. G.

Transactions - 7th World Biomaterials Congress. 2004. p. 1443.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

LeGeros, RZ, Grzanna, M, Polotsky, A, Lin, S & Frondoza, CG 2004, Effect of magnesium, zinc and fluoride ions on osteoblast proliferation and phenotype expression. in Transactions - 7th World Biomaterials Congress. pp. 1443, Transactions - 7th World Biomaterials Congress, Sydney, Australia, 5/17/04.
LeGeros RZ, Grzanna M, Polotsky A, Lin S, Frondoza CG. Effect of magnesium, zinc and fluoride ions on osteoblast proliferation and phenotype expression. In Transactions - 7th World Biomaterials Congress. 2004. p. 1443
LeGeros, R. Z. ; Grzanna, M. ; Polotsky, A. ; Lin, S. ; Frondoza, C. G. / Effect of magnesium, zinc and fluoride ions on osteoblast proliferation and phenotype expression. Transactions - 7th World Biomaterials Congress. 2004. pp. 1443
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