The role of cimetidine in decreasing PTH levels in uremic patients in haemodialysis is still controversial. In this study, five patients with chronic renal failure (CRF) in conservative treatment (creatinine 544 ± 64.4 μmol/l) received cimetidine (600 to 900 mg) for 12 weeks. Serum C-terminal PTH, calcium, phosphorus, creatinine and urea were determined one week before, during and two weeks after the treatment. Before treatment, PTH levels were elevated (7.0 ± 1.23 ng/ml) then they decreased during cimetidine administration, reaching significant lower levels (5.4 ± 0.97; p < 0.05) after 12 weeks. Calcium and phosphorus levels did not show any significant variation. Creatinine and urea concentrations increased from 10 to 12 weeks after cimetidine administration (p < 0.05), then fell to values not different from the control period 2 weeks after cimetindine was discontinued. These data indicate that cimetidine administration induces both a decrease in PTH levels and a reversible deterioration of renal function in patients with CRF in conservative treatment.
|Original language||English (US)|
|Number of pages||2|
|Journal||IRCS Medical Science|
|Publication status||Published - Jan 1 1981|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)