Effect of long term treatment with cimetidine on PTH levels and renal function in chronic renal failure

G. Garibotto, M. Giusti, Serena M Bagnasco, G. Deferrari

Research output: Contribution to journalArticle

Abstract

The role of cimetidine in decreasing PTH levels in uremic patients in haemodialysis is still controversial. In this study, five patients with chronic renal failure (CRF) in conservative treatment (creatinine 544 ± 64.4 μmol/l) received cimetidine (600 to 900 mg) for 12 weeks. Serum C-terminal PTH, calcium, phosphorus, creatinine and urea were determined one week before, during and two weeks after the treatment. Before treatment, PTH levels were elevated (7.0 ± 1.23 ng/ml) then they decreased during cimetidine administration, reaching significant lower levels (5.4 ± 0.97; p < 0.05) after 12 weeks. Calcium and phosphorus levels did not show any significant variation. Creatinine and urea concentrations increased from 10 to 12 weeks after cimetidine administration (p < 0.05), then fell to values not different from the control period 2 weeks after cimetindine was discontinued. These data indicate that cimetidine administration induces both a decrease in PTH levels and a reversible deterioration of renal function in patients with CRF in conservative treatment.

Original languageEnglish (US)
Pages (from-to)718-719
Number of pages2
JournalIRCS Medical Science
Volume9
Issue number8
Publication statusPublished - Jan 1 1981
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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