Effect of Long-Term Clopidogrel Treatment on Platelet Function and Inflammation in Patients Undergoing Coronary Arterial Stenting

Mark J. Antonino, Elisabeth Mahla, Kevin P. Bliden, Udaya S. Tantry, Paul A. Gurbel

Research output: Contribution to journalArticle

Abstract

A clopidogrel loading dose administered during stenting attenuates inflammation marker release. However, less is known of the anti-inflammatory effect of clopidogrel maintenance therapy. Platelet reactivity to adenosine diphosphate and inflammation markers were measured in 110 consecutive patients (69 clopidogrel-naive patients and 41 patients receiving long-term clopidogrel therapy for >6 months) before nonemergent stenting by turbidimetric aggregometry and flow cytometry and multianalyte profiling, respectively. All patients were treated with aspirin. Prestenting adenosine diphosphate-induced platelet aggregation, P-selectin, and activated glycoprotein IIb/IIIa expression were lower in patients receiving long-term clopidogrel therapy compared with the clopidogrel-naive group (p <0.001), accompanied by lower levels of selected inflammation markers (p ≤0.05). Additionally, there were strong correlations between platelet aggregation and flow cytometric measurements (p ≤0.04) and between specific inflammation markers (p ≤0.02). In conclusion, in addition to markedly lowering platelet reactivity to adenosine diphosphate, long-term clopidogrel therapy is associated with an anti-inflammatory effect.

Original languageEnglish (US)
Pages (from-to)1546-1550
Number of pages5
JournalAmerican Journal of Cardiology
Volume103
Issue number11
DOIs
StatePublished - Jun 1 2009

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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