Effect of Local Hypothermia on Early Wound Repair

Ramon M. Esclamado, Gregg A. Damiano, Charles W Cummings

Research output: Contribution to journalArticle

Abstract

Local hypothermia has been shown to enhance survival of pedicled skin flaps. The effect of prolonged local hypothermia on an important clinical correlate, wound healing, is examined in this study. Skin incisions were made on each flank of nine female pigs, and these incisions were closed primarily. A cooling pad was applied over the incisions on the right side of each animal, achieving an average dermal temperature of 35°C vs 39°C for the control side. Four animals were treated for 72 hours postoperatively; five pigs were treated for 7 days. Wound repair was evaluated by standard histologic techniques at 24 hours, 72 hours, 7 days, and 14 days. Control wounds in all animals demonstrated the normal progression of primary wound repair. We demonstrate that local hypothermia: (1) inhibits wound repair for the duration of its application; (2) is not detrimental to the early 2-week phase of wound healing if applied for 72 hours postoperatively; and (3) may have a beneficial effect by inhibiting inflammation through delay of the late inflammatory phase of wound healing.

Original languageEnglish (US)
Pages (from-to)803-808
Number of pages6
JournalArchives of Otolaryngology--Head and Neck Surgery
Volume116
Issue number7
DOIs
StatePublished - 1990
Externally publishedYes

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Hypothermia
Wound Healing
Wounds and Injuries
Swine
Histological Techniques
Skin
Surgical Flaps
Skin Temperature
Inflammation

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery

Cite this

Effect of Local Hypothermia on Early Wound Repair. / Esclamado, Ramon M.; Damiano, Gregg A.; Cummings, Charles W.

In: Archives of Otolaryngology--Head and Neck Surgery, Vol. 116, No. 7, 1990, p. 803-808.

Research output: Contribution to journalArticle

Esclamado, Ramon M. ; Damiano, Gregg A. ; Cummings, Charles W. / Effect of Local Hypothermia on Early Wound Repair. In: Archives of Otolaryngology--Head and Neck Surgery. 1990 ; Vol. 116, No. 7. pp. 803-808.
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