Effect of liposome-encapsulated hemoglobin on the development of endotoxin-induced shock in the rat

M. Whiteford; A. Spirig; A. Rudolph; L. Neville; F. Abdullah; G. Feuerstein; Reuven Rabinovici

Effect of liposome-encapsulated hemoglobin on the development of endotoxin-induced shock in the rat

M. Whiteford, A. Spirig, A. Rudolph, L. Neville, F. Abdullah, G. Feuerstein, Reuven Rabinovici

Research output: Contribution to journal › Article › peer-review

Abstract

Liposome-encapsulated hemoglobin (LEH) is an experimental oxygen-carrying resuscitation fluid. Because LEH is cleared from the circulation primarily by the reticuloendothelial system, its effect on the development of sepsis remains a major concern. Thus, the present study aimed to evaluate whether LEH modifies consequences of endotoxemia in the conscious normovolemic rat. LEH infusion at 10% of estimated blood volume (n = 10) did not affect mortality (30%, p <.05) and serum tumor necrosis factor-α levels (6204 ± 414, p <.05) induced by 3.6 mg/kg Escherichia coli endotoxin administered (intravenous bolus) 22 h later. In contrast, when a shorter LEH-endotoxin time interval (

Original language	English (US)
Pages (from-to)	428-433
Number of pages	6
Journal	Shock
Volume	9
Issue number	6
State	Published - Jun 1998
Externally published	Yes

ASJC Scopus subject areas

Physiology
Critical Care and Intensive Care Medicine

Cite this

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abstract = "Liposome-encapsulated hemoglobin (LEH) is an experimental oxygen-carrying resuscitation fluid. Because LEH is cleared from the circulation primarily by the reticuloendothelial system, its effect on the development of sepsis remains a major concern. Thus, the present study aimed to evaluate whether LEH modifies consequences of endotoxemia in the conscious normovolemic rat. LEH infusion at 10% of estimated blood volume (n = 10) did not affect mortality (30%, p <.05) and serum tumor necrosis factor-α levels (6204 ± 414, p <.05) induced by 3.6 mg/kg Escherichia coli endotoxin administered (intravenous bolus) 22 h later. In contrast, when a shorter LEH-endotoxin time interval (",

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T1 - Effect of liposome-encapsulated hemoglobin on the development of endotoxin-induced shock in the rat

AU - Whiteford, M.

AU - Spirig, A.

AU - Rudolph, A.

AU - Neville, L.

AU - Abdullah, F.

AU - Feuerstein, G.

AU - Rabinovici, Reuven

PY - 1998/6

Y1 - 1998/6

N2 - Liposome-encapsulated hemoglobin (LEH) is an experimental oxygen-carrying resuscitation fluid. Because LEH is cleared from the circulation primarily by the reticuloendothelial system, its effect on the development of sepsis remains a major concern. Thus, the present study aimed to evaluate whether LEH modifies consequences of endotoxemia in the conscious normovolemic rat. LEH infusion at 10% of estimated blood volume (n = 10) did not affect mortality (30%, p <.05) and serum tumor necrosis factor-α levels (6204 ± 414, p <.05) induced by 3.6 mg/kg Escherichia coli endotoxin administered (intravenous bolus) 22 h later. In contrast, when a shorter LEH-endotoxin time interval (

AB - Liposome-encapsulated hemoglobin (LEH) is an experimental oxygen-carrying resuscitation fluid. Because LEH is cleared from the circulation primarily by the reticuloendothelial system, its effect on the development of sepsis remains a major concern. Thus, the present study aimed to evaluate whether LEH modifies consequences of endotoxemia in the conscious normovolemic rat. LEH infusion at 10% of estimated blood volume (n = 10) did not affect mortality (30%, p <.05) and serum tumor necrosis factor-α levels (6204 ± 414, p <.05) induced by 3.6 mg/kg Escherichia coli endotoxin administered (intravenous bolus) 22 h later. In contrast, when a shorter LEH-endotoxin time interval (

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Effect of liposome-encapsulated hemoglobin on the development of endotoxin-induced shock in the rat

Abstract

ASJC Scopus subject areas

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