Effect of liposome-encapsulated hemoglobin on the development of endotoxin-induced shock in the rat

M. Whiteford, A. Spirig, A. Rudolph, L. Neville, F. Abdullah, G. Feuerstein, Reuven Rabinovici

Research output: Contribution to journalArticlepeer-review

Abstract

Liposome-encapsulated hemoglobin (LEH) is an experimental oxygen-carrying resuscitation fluid. Because LEH is cleared from the circulation primarily by the reticuloendothelial system, its effect on the development of sepsis remains a major concern. Thus, the present study aimed to evaluate whether LEH modifies consequences of endotoxemia in the conscious normovolemic rat. LEH infusion at 10% of estimated blood volume (n = 10) did not affect mortality (30%, p <.05) and serum tumor necrosis factor-α levels (6204 ± 414, p <.05) induced by 3.6 mg/kg Escherichia coli endotoxin administered (intravenous bolus) 22 h later. In contrast, when a shorter LEH-endotoxin time interval (

Original languageEnglish (US)
Pages (from-to)428-433
Number of pages6
JournalShock
Volume9
Issue number6
StatePublished - Jun 1998
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Critical Care and Intensive Care Medicine

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