Abstract
Liposome-encapsulated hemoglobin (LEH) is an experimental oxygen-carrying resuscitation fluid. Because LEH is cleared from the circulation primarily by the reticuloendothelial system, its effect on the development of sepsis remains a major concern. Thus, the present study aimed to evaluate whether LEH modifies consequences of endotoxemia in the conscious normovolemic rat. LEH infusion at 10% of estimated blood volume (n = 10) did not affect mortality (30%, p <.05) and serum tumor necrosis factor-α levels (6204 ± 414, p <.05) induced by 3.6 mg/kg Escherichia coli endotoxin administered (intravenous bolus) 22 h later. In contrast, when a shorter LEH-endotoxin time interval (
Original language | English (US) |
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Pages (from-to) | 428-433 |
Number of pages | 6 |
Journal | Shock |
Volume | 9 |
Issue number | 6 |
State | Published - Jun 1998 |
Externally published | Yes |
ASJC Scopus subject areas
- Physiology
- Critical Care and Intensive Care Medicine