TY - JOUR
T1 - Effect of Linoleic and Oleic Acids On Blood Pressure, Blood Viscosity, and Erythrocyte Cation Transport
AU - Sacks, Frank M.
AU - Stampfer, Meir J.
AU - Munoz, Alvaro
AU - McManus, Kathy
AU - Canessa, Mitzy
AU - Kass, Edward H.
N1 - Funding Information:
Supported by a Grant-in-Aid from the American Heart Association with funds provided in part by the Massachusetts affiliate (Drs. Kass and Sacks), HL-34593 (Dr. Sacks) and HL-25064 (Dr. Canessa). Dr. Sacks is currently a recipient ofa Clinician-Scientist Award from the American Heart Association.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1987/1/1
Y1 - 1987/1/1
N2 - It has been proposed that dietary linoleic acid lowers blood pressure (BP) by being converted to arachidonic acid and prostanoids of the two-ene series. We tested the effects of linoleic acid on plasma arachidonic acid, blood pressure, blood viscosity, and RBC cation transport. Oleic acid, the major dietary monounsaturated fat and which is not a prostanoid precursor, was used as a control. Seventeen adults consumed 23 g/d of linoleic acid or oleic acid provided by genetic variants of safflower seed, each for 4 weeks in a double-blind crossover design. Linoleic and oleic acids were enriched significantly in the plasma cholesteryl esters, phospholipids and triglycerides during the respective periods of supplementation but there was no increase in arachidonate. Mean BP was 116.1/76.8 during ingestion of oleic and 113.6/74.6 during ingestion of linoleic acid (p = 0.09 systolic, p = 0.12 diastolic). The power of the study was over 75% for detecting a significant (p < 0.05) effect of 4 mm Hg in systolic BP or diastolic BP. Whole blood and plasma viscosity, and RBC Li/Na countertransport, Na/K cotransport, and Na pump systems (Vmax) were unchanged during the protocol. Therefore, variations in dietary linoleic or oleic acids are unlikely to have major effects on BP or on several membrane-dependent erythrocyte functions related to hypertension.
AB - It has been proposed that dietary linoleic acid lowers blood pressure (BP) by being converted to arachidonic acid and prostanoids of the two-ene series. We tested the effects of linoleic acid on plasma arachidonic acid, blood pressure, blood viscosity, and RBC cation transport. Oleic acid, the major dietary monounsaturated fat and which is not a prostanoid precursor, was used as a control. Seventeen adults consumed 23 g/d of linoleic acid or oleic acid provided by genetic variants of safflower seed, each for 4 weeks in a double-blind crossover design. Linoleic and oleic acids were enriched significantly in the plasma cholesteryl esters, phospholipids and triglycerides during the respective periods of supplementation but there was no increase in arachidonate. Mean BP was 116.1/76.8 during ingestion of oleic and 113.6/74.6 during ingestion of linoleic acid (p = 0.09 systolic, p = 0.12 diastolic). The power of the study was over 75% for detecting a significant (p < 0.05) effect of 4 mm Hg in systolic BP or diastolic BP. Whole blood and plasma viscosity, and RBC Li/Na countertransport, Na/K cotransport, and Na pump systems (Vmax) were unchanged during the protocol. Therefore, variations in dietary linoleic or oleic acids are unlikely to have major effects on BP or on several membrane-dependent erythrocyte functions related to hypertension.
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U2 - 10.1080/07315724.1987.10720179
DO - 10.1080/07315724.1987.10720179
M3 - Article
C2 - 3584738
AN - SCOPUS:0023466076
SN - 0731-5724
VL - 6
SP - 179
EP - 185
JO - Journal of the American College of Nutrition
JF - Journal of the American College of Nutrition
IS - 2
ER -