Effect of lidoflazine on cerebral blood flow following twelve minutes total cerebral ischemia

J. Michael Dean, Paul J. Hoehner, Mark C. Rogers, Richard J. Traystman

Research output: Contribution to journalArticle

Abstract

Lidoflazine, a calcium channel blocker, was ad ministered to dogs following twelve minutes of cerebral ischemia, induced by aortic cross-clamping. The effects of lidoflazine (1 mg/kg i.v.) on cerebral blood flow following ischemia was studied in 15 anesthetized, mechanically ventilated dogs. Cerebral blood flow was measured with the radiolabclled microsphere technique before and 10, 30, 60, 90 and 150 minutes following ischemia. Cerebral blood flow increased in all brain regions following ischemia, but by 60 minutes had decreased to control values. Lidoflazine had no effect on this reperfusion phenomenon, or on the distribution of blood flow within the brain. Regional cerebral blood flow was also not altered by lidoflazine therapy. Our data demonstrate that this dose of lidoflazine has no effect on regional or total cerebral blood flow following 12 minutes of cerebral ischemia in dogs. These data do not support perfusion preservation as a mechanism of amelioration of neurologic injury after ischemia by this calcium channel blocker.

Original languageEnglish (US)
Pages (from-to)531-535
Number of pages5
JournalStroke
Volume15
Issue number3
StatePublished - 1984

Fingerprint

Cerebrovascular Circulation
Lidoflazine
Brain Ischemia
Ischemia
Calcium Channel Blockers
Dogs
Clergy
Nervous System Trauma
Regional Blood Flow
Brain
Microspheres
Constriction
Reperfusion
Perfusion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing
  • Neuroscience(all)

Cite this

Dean, J. M., Hoehner, P. J., Rogers, M. C., & Traystman, R. J. (1984). Effect of lidoflazine on cerebral blood flow following twelve minutes total cerebral ischemia. Stroke, 15(3), 531-535.

Effect of lidoflazine on cerebral blood flow following twelve minutes total cerebral ischemia. / Dean, J. Michael; Hoehner, Paul J.; Rogers, Mark C.; Traystman, Richard J.

In: Stroke, Vol. 15, No. 3, 1984, p. 531-535.

Research output: Contribution to journalArticle

Dean, JM, Hoehner, PJ, Rogers, MC & Traystman, RJ 1984, 'Effect of lidoflazine on cerebral blood flow following twelve minutes total cerebral ischemia', Stroke, vol. 15, no. 3, pp. 531-535.
Dean JM, Hoehner PJ, Rogers MC, Traystman RJ. Effect of lidoflazine on cerebral blood flow following twelve minutes total cerebral ischemia. Stroke. 1984;15(3):531-535.
Dean, J. Michael ; Hoehner, Paul J. ; Rogers, Mark C. ; Traystman, Richard J. / Effect of lidoflazine on cerebral blood flow following twelve minutes total cerebral ischemia. In: Stroke. 1984 ; Vol. 15, No. 3. pp. 531-535.
@article{9e080849c59748b2bab8ce6f84764860,
title = "Effect of lidoflazine on cerebral blood flow following twelve minutes total cerebral ischemia",
abstract = "Lidoflazine, a calcium channel blocker, was ad ministered to dogs following twelve minutes of cerebral ischemia, induced by aortic cross-clamping. The effects of lidoflazine (1 mg/kg i.v.) on cerebral blood flow following ischemia was studied in 15 anesthetized, mechanically ventilated dogs. Cerebral blood flow was measured with the radiolabclled microsphere technique before and 10, 30, 60, 90 and 150 minutes following ischemia. Cerebral blood flow increased in all brain regions following ischemia, but by 60 minutes had decreased to control values. Lidoflazine had no effect on this reperfusion phenomenon, or on the distribution of blood flow within the brain. Regional cerebral blood flow was also not altered by lidoflazine therapy. Our data demonstrate that this dose of lidoflazine has no effect on regional or total cerebral blood flow following 12 minutes of cerebral ischemia in dogs. These data do not support perfusion preservation as a mechanism of amelioration of neurologic injury after ischemia by this calcium channel blocker.",
author = "Dean, {J. Michael} and Hoehner, {Paul J.} and Rogers, {Mark C.} and Traystman, {Richard J.}",
year = "1984",
language = "English (US)",
volume = "15",
pages = "531--535",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Effect of lidoflazine on cerebral blood flow following twelve minutes total cerebral ischemia

AU - Dean, J. Michael

AU - Hoehner, Paul J.

AU - Rogers, Mark C.

AU - Traystman, Richard J.

PY - 1984

Y1 - 1984

N2 - Lidoflazine, a calcium channel blocker, was ad ministered to dogs following twelve minutes of cerebral ischemia, induced by aortic cross-clamping. The effects of lidoflazine (1 mg/kg i.v.) on cerebral blood flow following ischemia was studied in 15 anesthetized, mechanically ventilated dogs. Cerebral blood flow was measured with the radiolabclled microsphere technique before and 10, 30, 60, 90 and 150 minutes following ischemia. Cerebral blood flow increased in all brain regions following ischemia, but by 60 minutes had decreased to control values. Lidoflazine had no effect on this reperfusion phenomenon, or on the distribution of blood flow within the brain. Regional cerebral blood flow was also not altered by lidoflazine therapy. Our data demonstrate that this dose of lidoflazine has no effect on regional or total cerebral blood flow following 12 minutes of cerebral ischemia in dogs. These data do not support perfusion preservation as a mechanism of amelioration of neurologic injury after ischemia by this calcium channel blocker.

AB - Lidoflazine, a calcium channel blocker, was ad ministered to dogs following twelve minutes of cerebral ischemia, induced by aortic cross-clamping. The effects of lidoflazine (1 mg/kg i.v.) on cerebral blood flow following ischemia was studied in 15 anesthetized, mechanically ventilated dogs. Cerebral blood flow was measured with the radiolabclled microsphere technique before and 10, 30, 60, 90 and 150 minutes following ischemia. Cerebral blood flow increased in all brain regions following ischemia, but by 60 minutes had decreased to control values. Lidoflazine had no effect on this reperfusion phenomenon, or on the distribution of blood flow within the brain. Regional cerebral blood flow was also not altered by lidoflazine therapy. Our data demonstrate that this dose of lidoflazine has no effect on regional or total cerebral blood flow following 12 minutes of cerebral ischemia in dogs. These data do not support perfusion preservation as a mechanism of amelioration of neurologic injury after ischemia by this calcium channel blocker.

UR - http://www.scopus.com/inward/record.url?scp=0021270039&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021270039&partnerID=8YFLogxK

M3 - Article

C2 - 6427983

AN - SCOPUS:0021270039

VL - 15

SP - 531

EP - 535

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 3

ER -