Effect of l-norepinephrine and adrenergic potentiators on the aqueous humor dynamics of man

Irvin Paul Pollack

Research output: Contribution to journalArticlepeer-review

Abstract

Topical administration of protriptyline 0.025% and 0.05%, and a test drug, MK-940, failed to produce any significant change in the intraocular pressure when applied twice daily to human subjects. Similarly, MK-940 failed to potentiate the effect of topically applied l-norepinephrine 2%. When applied twice daily as the free base, l-norepinephrine 2% produced a significant decrease in intraocular pressure and outflow resistance in persons with ocular hypertension. The amount of pressure reduction was related to the height of the initial intraocular pressure.

Original languageEnglish (US)
Pages (from-to)641-647
Number of pages7
JournalAmerican journal of ophthalmology
Volume76
Issue number5
DOIs
StatePublished - Nov 1973

ASJC Scopus subject areas

  • Ophthalmology

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