TY - JOUR
T1 - Effect of intrathoracic pressure on pressure volume characteristics of the lung in man
AU - Goldberg, H. S.
AU - Mitzner, W.
AU - Adams, K.
AU - Menkes, H.
AU - Lichtenstein, S.
AU - Permutt, S.
PY - 1975/1/1
Y1 - 1975/1/1
N2 - Quasi static pressure volume (PV) curves in normal seated human subjects were determined with pressure at the airway opening (Pao) set below (negative pressure), above (positive pressure) or equal to ambient pressure. Dynamic compliance (Cdyn) during controlled continuous negative pressure breathing (CNPB) was also studied. Quasi static PV curves at negative pressure were decreased in slope, reflected a decrease in total lung capacity, and intersected the PV curve obtained at ambient Pao. At positive pressure, the PV curves showed an increase in slope and an increase in total lung capacity. During CNPB, a fall in Cdyn was found. The fall in Cdyn was rapid and persisted for the duration of CNPB. Cdyn promptly returned to control levels when Pao was adjusted to ambient pressure.
AB - Quasi static pressure volume (PV) curves in normal seated human subjects were determined with pressure at the airway opening (Pao) set below (negative pressure), above (positive pressure) or equal to ambient pressure. Dynamic compliance (Cdyn) during controlled continuous negative pressure breathing (CNPB) was also studied. Quasi static PV curves at negative pressure were decreased in slope, reflected a decrease in total lung capacity, and intersected the PV curve obtained at ambient Pao. At positive pressure, the PV curves showed an increase in slope and an increase in total lung capacity. During CNPB, a fall in Cdyn was found. The fall in Cdyn was rapid and persisted for the duration of CNPB. Cdyn promptly returned to control levels when Pao was adjusted to ambient pressure.
UR - http://www.scopus.com/inward/record.url?scp=0016641311&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016641311&partnerID=8YFLogxK
U2 - 10.1152/jappl.1975.38.3.411
DO - 10.1152/jappl.1975.38.3.411
M3 - Article
C2 - 1150554
AN - SCOPUS:0016641311
VL - 38
SP - 411
EP - 417
JO - Advances in Water Resources
JF - Advances in Water Resources
SN - 0309-1708
IS - 3
ER -