Abstract
Quasi static pressure volume (PV) curves in normal seated human subjects were determined with pressure at the airway opening (Pao) set below (negative pressure), above (positive pressure) or equal to ambient pressure. Dynamic compliance (Cdyn) during controlled continuous negative pressure breathing (CNPB) was also studied. Quasi static PV curves at negative pressure were decreased in slope, reflected a decrease in total lung capacity, and intersected the PV curve obtained at ambient Pao. At positive pressure, the PV curves showed an increase in slope and an increase in total lung capacity. During CNPB, a fall in Cdyn was found. The fall in Cdyn was rapid and persisted for the duration of CNPB. Cdyn promptly returned to control levels when Pao was adjusted to ambient pressure.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 411-417 |
| Number of pages | 7 |
| Journal | Journal of Applied Physiology |
| Volume | 38 |
| Issue number | 3 |
| State | Published - 1975 |
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ASJC Scopus subject areas
- Physiology
- Endocrinology
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation
Cite this
Effect of intrathoracic pressure on pressure volume characteristics of the lung in man. / Goldberg, H. S.; Mitzner, Wayne A; Adams, K.; Menkes, H.; Lichtenstein, S.; Permutt, S.
In: Journal of Applied Physiology, Vol. 38, No. 3, 1975, p. 411-417.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of intrathoracic pressure on pressure volume characteristics of the lung in man
AU - Goldberg, H. S.
AU - Mitzner, Wayne A
AU - Adams, K.
AU - Menkes, H.
AU - Lichtenstein, S.
AU - Permutt, S.
PY - 1975
Y1 - 1975
N2 - Quasi static pressure volume (PV) curves in normal seated human subjects were determined with pressure at the airway opening (Pao) set below (negative pressure), above (positive pressure) or equal to ambient pressure. Dynamic compliance (Cdyn) during controlled continuous negative pressure breathing (CNPB) was also studied. Quasi static PV curves at negative pressure were decreased in slope, reflected a decrease in total lung capacity, and intersected the PV curve obtained at ambient Pao. At positive pressure, the PV curves showed an increase in slope and an increase in total lung capacity. During CNPB, a fall in Cdyn was found. The fall in Cdyn was rapid and persisted for the duration of CNPB. Cdyn promptly returned to control levels when Pao was adjusted to ambient pressure.
AB - Quasi static pressure volume (PV) curves in normal seated human subjects were determined with pressure at the airway opening (Pao) set below (negative pressure), above (positive pressure) or equal to ambient pressure. Dynamic compliance (Cdyn) during controlled continuous negative pressure breathing (CNPB) was also studied. Quasi static PV curves at negative pressure were decreased in slope, reflected a decrease in total lung capacity, and intersected the PV curve obtained at ambient Pao. At positive pressure, the PV curves showed an increase in slope and an increase in total lung capacity. During CNPB, a fall in Cdyn was found. The fall in Cdyn was rapid and persisted for the duration of CNPB. Cdyn promptly returned to control levels when Pao was adjusted to ambient pressure.
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UR - http://www.scopus.com/inward/citedby.url?scp=0016641311&partnerID=8YFLogxK
M3 - Article
VL - 38
SP - 411
EP - 417
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 0161-7567
IS - 3
ER -