TY - JOUR
T1 - Effect of intra-alveolar meconium on pulmonary surface tension properties
AU - Ter Chen, C.
AU - Toung, T. J.K.
AU - Rogers, M. C.
PY - 1985
Y1 - 1985
N2 - To evaluate the effect of meconium on pulmonary surface tension properties, the mechanics of 30 excised, separated canine pulmonary lobes were studied. Meconia were blended in normal saline to produce solutions of 10% and 20%. Solutions were filtered to remove large particles and instilled endobronchially into the canine lobes. The static pressure-volume deflation curve of each lobe was determined before and 4 h after instillation of either normal saline or meconium solution. In the saline control group (eight lobes), the curve was essentially unchanged before and after instillation. In the 10% meconium group (14 lobes), the curve was significantly depressed after instillation, especially at a transpulmonary airway pressure of 10 cm H1O )p < .05) and 5 cm H2O (p < .005). In the 20% meconium group (eight lobes), the depression of the pressure-volume curve was essentially the same as that of the 10% solution group. It is concluded that meconium depresses the surface-active properties of the alveolar linings.
AB - To evaluate the effect of meconium on pulmonary surface tension properties, the mechanics of 30 excised, separated canine pulmonary lobes were studied. Meconia were blended in normal saline to produce solutions of 10% and 20%. Solutions were filtered to remove large particles and instilled endobronchially into the canine lobes. The static pressure-volume deflation curve of each lobe was determined before and 4 h after instillation of either normal saline or meconium solution. In the saline control group (eight lobes), the curve was essentially unchanged before and after instillation. In the 10% meconium group (14 lobes), the curve was significantly depressed after instillation, especially at a transpulmonary airway pressure of 10 cm H1O )p < .05) and 5 cm H2O (p < .005). In the 20% meconium group (eight lobes), the depression of the pressure-volume curve was essentially the same as that of the 10% solution group. It is concluded that meconium depresses the surface-active properties of the alveolar linings.
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U2 - 10.1097/00003246-198504000-00005
DO - 10.1097/00003246-198504000-00005
M3 - Article
C2 - 3979070
AN - SCOPUS:0021953722
SN - 0090-3493
VL - 13
SP - 233
EP - 236
JO - Critical care medicine
JF - Critical care medicine
IS - 4
ER -