TY - JOUR
T1 - Effect of influenza vaccine on tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in older adults
AU - Keshtkar-Jahromi, Maryam
AU - Ouyang, Min
AU - Keshtkarjahromi, Marzieh
AU - Almed, Samah
AU - Li, Huifen
AU - Walston, Jeremy D.
AU - Rios, Rebeca
AU - Leng, Sean X.
N1 - Funding Information:
This work was supported in part by NIH grant R01IA108907 (PI: Sean X. Leng] and funding from the Milstein Medical Asian American Partnership (MMAAP) Foundation ( http://www.mmaapf.org ) to Drs. Sean X. Leng and Min Ouyang. Dr. Min Ouyang is an Irma and Paul Milstein Program for Senior Health fellow supported by the MMAAP Foundation ( http://www.mmaapf.org ).
Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2018/4/12
Y1 - 2018/4/12
N2 - Influenza immunization is recommended for older adults annually, and has been reported to have cardiovascular protective effects. TNF-related weak inducer of apoptosis (TWEAK), an inflammatory mediator implicated in the development of cardiovascular diseases, could be a mechanism for such effect. The objective of this study was to evaluate the effect of influenza vaccine on TWEAK levels. Older persons over 70 years of age were recruited during 2007–2008 influenza season and immunized with the standard dose trivalent inactivated influenza vaccine. Frailty was evaluated using a validated set of criteria. Sera were collected immediately before and during the 4th week after vaccination. Pre- and post-vaccination levels of TWEAK, soluble CD163 (sCD163) and strain-specific influenza antibody titers were measured in 69 participants. Multiple regression analyses were employed to examine the effect of influenza vaccine on TWEAK and sCD163, adjusting for age, sex, and hypertension. Post-vaccination TWEAK [mean ± standard deviation (SD) = 591.7 ± 290.1 pg/ml] was significantly lower than pre-vaccination level (690.6 ± 330.0 pg/ml) (p =.003). No significant difference was observed between pre and post-vaccination sCD163 levels (p =.71). Post-vaccination TWEAK levels were significantly higher in men (p =.01) and in participants with college or higher level of education (p =.044). There was no significant difference in post-vaccination TWEAK according to other demographics or pre-existing medical conditions. A 2-fold or greater antibody titer against H1N1 vaccine strain was associated with a more pronounced reduction in TWEAK at the p <.10 level (p =.091). A time by frailty interaction term (p =.091) indicated that the vaccination-induced reduction of TWEAK was greatest among frail individuals. These results of this observational study indicate that the impact of Influenza vaccine on TWEAK, including the role of specific antibody responses of specific vaccine strains and frailty status, warrants further investigation. Such investigation may elucidate whether this effect plays a role in mediating cardiovascular protection of influenza vaccination.
AB - Influenza immunization is recommended for older adults annually, and has been reported to have cardiovascular protective effects. TNF-related weak inducer of apoptosis (TWEAK), an inflammatory mediator implicated in the development of cardiovascular diseases, could be a mechanism for such effect. The objective of this study was to evaluate the effect of influenza vaccine on TWEAK levels. Older persons over 70 years of age were recruited during 2007–2008 influenza season and immunized with the standard dose trivalent inactivated influenza vaccine. Frailty was evaluated using a validated set of criteria. Sera were collected immediately before and during the 4th week after vaccination. Pre- and post-vaccination levels of TWEAK, soluble CD163 (sCD163) and strain-specific influenza antibody titers were measured in 69 participants. Multiple regression analyses were employed to examine the effect of influenza vaccine on TWEAK and sCD163, adjusting for age, sex, and hypertension. Post-vaccination TWEAK [mean ± standard deviation (SD) = 591.7 ± 290.1 pg/ml] was significantly lower than pre-vaccination level (690.6 ± 330.0 pg/ml) (p =.003). No significant difference was observed between pre and post-vaccination sCD163 levels (p =.71). Post-vaccination TWEAK levels were significantly higher in men (p =.01) and in participants with college or higher level of education (p =.044). There was no significant difference in post-vaccination TWEAK according to other demographics or pre-existing medical conditions. A 2-fold or greater antibody titer against H1N1 vaccine strain was associated with a more pronounced reduction in TWEAK at the p <.10 level (p =.091). A time by frailty interaction term (p =.091) indicated that the vaccination-induced reduction of TWEAK was greatest among frail individuals. These results of this observational study indicate that the impact of Influenza vaccine on TWEAK, including the role of specific antibody responses of specific vaccine strains and frailty status, warrants further investigation. Such investigation may elucidate whether this effect plays a role in mediating cardiovascular protection of influenza vaccination.
KW - Cardiovascular disease
KW - Frailty
KW - Influenza vaccine
KW - TWEAK
KW - sCD163
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U2 - 10.1016/j.vaccine.2017.11.045
DO - 10.1016/j.vaccine.2017.11.045
M3 - Article
C2 - 29548604
AN - SCOPUS:85043457773
SN - 0264-410X
VL - 36
SP - 2220
EP - 2225
JO - Vaccine
JF - Vaccine
IS - 16
ER -